1-methylethyl 4-{[7-(4-bromo-2-fluorophenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}-1-piperidine carboxylate

Base Information

Chemical Name:1-methylethyl 4-{[7-(4-bromo-2-fluorophenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}-1-piperidine carboxylate
CAS No.:1001397-39-2
Molecular Formula:C₂₁H₂₄BrFN₄O₃
Molecular Weight:479.349
Hs Code.:

Synonyms:1-methylethyl 4-{[7-(4-bromo-2-fluorophenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}-1-piperidine carboxylate

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Chemical Property of 1-methylethyl 4-{[7-(4-bromo-2-fluorophenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}-1-piperidine carboxylate

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Technology Process of 1-methylethyl 4-{[7-(4-bromo-2-fluorophenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}-1-piperidine carboxylate

There total 6 articles about 1-methylethyl 4-{[7-(4-bromo-2-fluorophenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}-1-piperidine carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1001397-39-2
1-methylethyl 4-{[7-(4-bromo-2-fluorophenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}-1-piperidine carboxylate

Guidance literature:

Reference yield:

: 1001397-37-0
7-(4-bromo-2-fluorophenyl)-4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

: 832715-51-2
isopropyl 4-hydroxypiperidine-1-carboxylate

: 1001397-39-2
1-methylethyl 4-{[7-(4-bromo-2-fluorophenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}-1-piperidine carboxylate

Guidance literature:: isopropyl 4-hydroxypiperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; for 0.5h; Reflux;

7-(4-bromo-2-fluorophenyl)-4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine; In tetrahydrofuran; mineral oil; at 20 ℃; for 1.5h; Reflux;
DOI:10.1021/jm301404a

Reference yield:

: 16019-30-0
6-hydroxy-5-(2-propen-1-yl)-4(1H)-pyrimidinone

: 1001397-39-2
1-methylethyl 4-{[7-(4-bromo-2-fluorophenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}-1-piperidine carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 4 h / Inert atmosphere; Reflux

2.1: sodium hydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

3.1: ozone / dichloromethane; methanol / -78 - 20 °C / Inert atmosphere

4.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 15 h / 5 - 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / Reflux

5.2: 1.5 h / 20 °C / Reflux

With sodium hydride; ozone; triethylamine; trichlorophosphate; Methanesulfonic anhydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm301404a