N-(2-bromoethyl)-N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide

Base Information

Chemical Name:N-(2-bromoethyl)-N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide
CAS No.:862120-72-7
Molecular Formula:C₁₉H₂₁BrF₃N₃O₅S
Molecular Weight:540.358
Hs Code.:

Synonyms:N-(2-bromoethyl)-N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-bromoethyl)-N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide

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Technology Process of N-(2-bromoethyl)-N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide

There total 5 articles about N-(2-bromoethyl)-N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 862120-71-6
N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide

: 106-93-4
ethylene dibromide

: 862120-72-7
N-(2-bromoethyl)-N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

Reference yield:

: 844640-04-6
2-tert-butoxy-6-chloro-4-(trifluoromethyl)pyridine

: 862120-72-7
N-(2-bromoethyl)-N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

2: ammonium hydroxide; hydrogen / ethanol / 6 h / 20 °C / 3102.97 Torr

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 844640-05-7
6-tert-butoxy-4-(trifluoromethyl)pyridine-2-carbonitrile

: 862120-72-7
N-(2-bromoethyl)-N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide; hydrogen / ethanol / 6 h / 20 °C / 3102.97 Torr

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

With ammonium hydroxide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;