(2-{2-[3-(3-hydroxypropoxy)-2-di-(ethoxycarbonylmethyl)aminophenoxy]ethoxy}-6-(3-hydroxypropoxy)-N,N-di(ethoxycarbonylmethyl)benzenamine)

Base Information

• Chemical Name: (2-{2-[3-(3-hydroxypropoxy)-2-di-(ethoxycarbonylmethyl)aminophenoxy]ethoxy}-6-(3-hydroxypropoxy)-N,N-di(ethoxycarbonylmethyl)benzenamine)
• CAS No.: 222192-35-0
• Molecular Formula: C₃₆H₅₂N₂O₁₄
• Molecular Weight: 736.814
• Mol file: 222192-35-0.mol

Synonyms:(2-{2-[3-(3-hydroxypropoxy)-2-di-(ethoxycarbonylmethyl)aminophenoxy]ethoxy}-6-(3-hydroxypropoxy)-N,N-di(ethoxycarbonylmethyl)benzenamine)

Chemical Property of (2-{2-[3-(3-hydroxypropoxy)-2-di-(ethoxycarbonylmethyl)aminophenoxy]ethoxy}-6-(3-hydroxypropoxy)-N,N-di(ethoxycarbonylmethyl)benzenamine)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{2-[3-(3-hydroxypropoxy)-2-di-(ethoxycarbonylmethyl)aminophenoxy]ethoxy}-6-(3-hydroxypropoxy)-N,N-di(ethoxycarbonylmethyl)benzenamine)

There total 1 articles about (2-{2-[3-(3-hydroxypropoxy)-2-di-(ethoxycarbonylmethyl)aminophenoxy]ethoxy}-6-(3-hydroxypropoxy)-N,N-di(ethoxycarbonylmethyl)benzenamine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl bromoacetate (105-36-2) + 3-(2-amino-3-{2-[2-amino-3-(3-hydroxy-propoxy)-phenoxy]-ethoxy}-phenoxy)-propan-1-ol (222192-34-9) → (2-{2-[3-(3-hydroxypropoxy)-2-di-(ethoxycarbonylmethyl)aminophenoxy]ethoxy}-6-(3-hydroxypropoxy)-N,N-di(ethoxycarbonylmethyl)benzenamine) (222192-35-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; Yield given;

DOI:10.1021/ja983702l

Reference yield: 60.0%

(2-{2-[3-(3-hydroxypropoxy)-2-di-(ethoxycarbonylmethyl)aminophenoxy]ethoxy}-6-(3-hydroxypropoxy)-N,N-di(ethoxycarbonylmethyl)benzenamine) (222192-35-0) → 2-{2-[3-(3-bromopropoxy)-2-di(ethoxycarbonylmethyl)-aminophenoxy]ethoxy}-6-(3-bromopropoxy)-N,N-di-(ethoxycarbonylmethyl)benzenamine (222192-36-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In diethyl ether;

DOI:10.1021/ja983702l

Reference yield:

(2-{2-[3-(3-hydroxypropoxy)-2-di-(ethoxycarbonylmethyl)aminophenoxy]ethoxy}-6-(3-hydroxypropoxy)-N,N-di(ethoxycarbonylmethyl)benzenamine) (222192-35-0) → ({2-(2-{2-(Bis-ethoxycarbonylmethyl-amino)-3-[3-(1,4,7,10-tetraaza-cyclododec-1-yl)-propoxy]-phenoxy}-ethoxy)-6-[3-(1,4,7,10-tetraaza-cyclododec-1-yl)-propoxy]-phenyl}-ethoxycarbonylmethyl-amino)-acetic acid ethyl ester (222192-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / CBr₄, PPh₃ / diethyl ether

2: 80 percent / CHCl₃

With carbon tetrabromide; triphenylphosphine; In diethyl ether; chloroform;

DOI:10.1021/ja983702l

upstream raw materials:

ethyl bromoacetate

3-(2-amino-3-{2-[2-amino-3-(3-hydroxy-propoxy)-phenoxy]-ethoxy}-phenoxy)-propan-1-ol

Downstream raw materials:

2-{2-[3-(3-bromopropoxy)-2-di(ethoxycarbonylmethyl)-aminophenoxy]ethoxy}-6-(3-bromopropoxy)-N,N-di-(ethoxycarbonylmethyl)benzenamine

({2-(2-{2-(Bis-ethoxycarbonylmethyl-amino)-3-[3-(1,4,7,10-tetraaza-cyclododec-1-yl)-propoxy]-phenoxy}-ethoxy)-6-[3-(1,4,7,10-tetraaza-cyclododec-1-yl)-propoxy]-phenyl}-ethoxycarbonylmethyl-amino)-acetic acid ethyl ester