(R)-2-((R)-(tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)pentanoic acid

Base Information

Chemical Name:(R)-2-((R)-(tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)pentanoic acid
CAS No.:1200722-75-3
Molecular Formula:C₁₈H₂₇NO₅
Molecular Weight:337.416
Hs Code.:

Synonyms:(R)-2-((R)-(tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)pentanoic acid

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Chemical Property of (R)-2-((R)-(tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)pentanoic acid

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Technology Process of (R)-2-((R)-(tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)pentanoic acid

There total 1 articles about (R)-2-((R)-(tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1200722-29-7
tert-butyl (1R,2R)-2-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-1-(4-methoxyphenyl)pentylcarbamate

: 1200722-75-3
(R)-2-((R)-(tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)pentanoic acid

Guidance literature:: tert-butyl (1R,2R)-2-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-1-(4-methoxyphenyl)pentylcarbamate; With lithium hydroxide monohydrate; water; dihydrogen peroxide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With potassium hydrogensulfate; In water; at 20 ℃; pH=1 - 2; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2009.09.072

Reference yield: 88.0%

: 67-56-1
methanol

: 1200722-75-3
(R)-2-((R)-(tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)pentanoic acid

: 1200723-11-0
(1R,2R)-2-(methoxycarbonyl)-1-(4-methoxyphenyl)pentan-1-amine hydrochloride

Guidance literature:: With thionyl chloride; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2009.09.072

Reference yield: 80.0%

: 1200722-75-3
(R)-2-((R)-(tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)pentanoic acid

: 2491-20-5
L-alanine methyl ester hydrochloride

: 1200723-05-2
(S)-methyl-2-((R)-2-((R)-(tert-butoxycarbonyl amino)(4-methoxyphenyl)methyl)pentanamido)propanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 27h; Inert atmosphere;
DOI:10.1016/j.tet.2009.09.072