tert-butyl 2-(6-amino-1-(2-(4-(4-(2-methoxyethoxy) phenyl) piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)hydrazine carboxylate

Base Information

Chemical Name:tert-butyl 2-(6-amino-1-(2-(4-(4-(2-methoxyethoxy) phenyl) piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)hydrazine carboxylate
CAS No.:929884-33-3
Molecular Formula:C₂₅H₃₇N₉O₄
Molecular Weight:527.627
Hs Code.:

Synonyms:tert-butyl 2-(6-amino-1-(2-(4-(4-(2-methoxyethoxy) phenyl) piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)hydrazine carboxylate

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Chemical Property of tert-butyl 2-(6-amino-1-(2-(4-(4-(2-methoxyethoxy) phenyl) piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)hydrazine carboxylate

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Technology Process of tert-butyl 2-(6-amino-1-(2-(4-(4-(2-methoxyethoxy) phenyl) piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)hydrazine carboxylate

There total 4 articles about tert-butyl 2-(6-amino-1-(2-(4-(4-(2-methoxyethoxy) phenyl) piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)hydrazine carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 2-(2-amino-6-chloro-5-formylpyrimidin-4-yl)hydrazine carboxylate

: 1-(2-hydrazinylethyl)-4-(4-(2-methoxyethoxy)phenyl)piperazine hydrochloride

: 929884-33-3
tert-butyl 2-(6-amino-1-(2-(4-(4-(2-methoxyethoxy) phenyl) piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)hydrazine carboxylate

Guidance literature:: 1-(2-hydrazinylethyl)-4-(4-(2-methoxyethoxy)phenyl)piperazine hydrochloride; With sodium carbonate; In acetonitrile; at 25 - 30 ℃; for 30h;

tert-butyl 2-(2-amino-6-chloro-5-formylpyrimidin-4-yl)hydrazine carboxylate; In acetonitrile; at 80 ℃;

Reference yield:

: 5604-46-6
2-amino-4,6-dichloropyrimidine-5-carboxaldehyde

: 929884-33-3
tert-butyl 2-(6-amino-1-(2-(4-(4-(2-methoxyethoxy) phenyl) piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)hydrazine carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / water; tetrahydrofuran / 50 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

3: N,N-dimethyl-formamide / 48 h / 20 - 80 °C

4: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 100 °C

With hydrazine hydrate; sodium hydride; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 929884-17-3
4-chloro-1-(2-chloroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

: 929884-33-3
tert-butyl 2-(6-amino-1-(2-(4-(4-(2-methoxyethoxy) phenyl) piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)hydrazine carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 48 h / 20 - 80 °C

2: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 100 °C

With N-ethyl-N,N-diisopropylamine; potassium iodide; In N,N-dimethyl-formamide;