(S)-N'-(6-amino-1-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-5-oxotetrahydrofuran-2-carbohydrazide

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Chemical Name:(S)-N'-(6-amino-1-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-5-oxotetrahydrofuran-2-carbohydrazide
CAS No.:1402054-50-5
Molecular Formula:C₂₅H₃₃N₉O₅
Molecular Weight:539.594
Hs Code.:

Synonyms:(S)-N'-(6-amino-1-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-5-oxotetrahydrofuran-2-carbohydrazide

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Chemical Property of (S)-N'-(6-amino-1-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-5-oxotetrahydrofuran-2-carbohydrazide

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Technology Process of (S)-N'-(6-amino-1-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-5-oxotetrahydrofuran-2-carbohydrazide

There total 5 articles about (S)-N'-(6-amino-1-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-5-oxotetrahydrofuran-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 21461-84-7
(2S)-tetrahydro-5-oxofuran-2-carboxylic acid

: 929884-34-4
4-hydrazinyl-1-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

: 1402054-50-5
(S)-N'-(6-amino-1-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-5-oxotetrahydrofuran-2-carbohydrazide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield:

: 929884-17-3
4-chloro-1-(2-chloroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

: 1402054-50-5
(S)-N'-(6-amino-1-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-5-oxotetrahydrofuran-2-carbohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 48 h / 20 - 80 °C

2: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 100 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 5.5 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 14 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 100644-65-3
4-chloro-1H-pyrazolo[3,4-d]pyrimidine-6-amine

: 1402054-50-5
(S)-N'-(6-amino-1-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-5-oxotetrahydrofuran-2-carbohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

2: N,N-dimethyl-formamide / 48 h / 20 - 80 °C

3: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 100 °C

4: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 5.5 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 14 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;