Methyl-7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate

Base Information

Chemical Name:Methyl-7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate
CAS No.:1312605-91-6
Molecular Formula:C₁₇H₁₃FN₂O₄S
Molecular Weight:360.366
Hs Code.:

Synonyms:Methyl-7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate

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Chemical Property of Methyl-7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate

Chemical Property:

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Technology Process of Methyl-7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate

There total 9 articles about Methyl-7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1289114-66-4
3-amino-5-fluoropicolinaldehyde

: 1312605-87-0
methyl 3-(2-(methylsulfonyl)phenyl)-3-oxopropanoate

: 1312605-91-6
Methyl-7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate

Guidance literature:: With cerium(III) chloride heptahydrate; at 100 ℃; for 3h;

Reference yield:

: 1312605-88-1
5-fluoro-3-nitro-2-vinylpyridine

: 1312605-91-6
Methyl-7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; tetrahydrofuran / 6 h / 25 °C

2: sodium periodate; water / tert-butyl alcohol; tetrahydrofuran / 8 h / 25 °C

3: toluene-4-sulfonic acid / toluene / 25 - 120 °C

4: hydrogen / palladium on carbon / ethanol / 25 °C / Inert atmosphere

5: water; lithium chloride / dimethyl sulfoxide / 16 h / 90 °C

6: cerium(III) chloride heptahydrate / 3 h / 100 °C

With sodium periodate; osmium(VIII) oxide; cerium(III) chloride heptahydrate; water; hydrogen; 4-methylmorpholine N-oxide; lithium chloride; palladium on carbon; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dimethyl sulfoxide; toluene; tert-butyl alcohol;

Reference yield:

: 1289047-69-3
5-fluoro-3-nitropicolinaldehyde

: 1312605-91-6
Methyl-7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 25 - 120 °C

2: hydrogen / palladium on carbon / ethanol / 25 °C / Inert atmosphere

3: water; lithium chloride / dimethyl sulfoxide / 16 h / 90 °C

4: cerium(III) chloride heptahydrate / 3 h / 100 °C

With cerium(III) chloride heptahydrate; water; hydrogen; lithium chloride; palladium on carbon; toluene-4-sulfonic acid; In ethanol; dimethyl sulfoxide; toluene;