Technology Process of methyl (7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol
There total 13 articles about methyl (7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde; methylmagnesium bromide;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
With
ammonium chloride;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; tetrahydrofuran / 6 h / 25 °C
2: sodium periodate; water / tert-butyl alcohol; tetrahydrofuran / 8 h / 25 °C
3: toluene-4-sulfonic acid / toluene / 25 - 120 °C
4: hydrogen / palladium on carbon / ethanol / 25 °C / Inert atmosphere
5: water; lithium chloride / dimethyl sulfoxide / 16 h / 90 °C
6: cerium(III) chloride heptahydrate / 3 h / 100 °C
7: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C
8: dipyridinium dichromate / dichloromethane / 25 °C
9: tetrahydrofuran / 2 h / 0 °C
With
sodium periodate; osmium(VIII) oxide; dipyridinium dichromate; cerium(III) chloride heptahydrate; water; hydrogen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; lithium chloride;
palladium on carbon; toluene-4-sulfonic acid;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; toluene; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere
2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; tetrahydrofuran / 6 h / 25 °C
3: sodium periodate; water / tert-butyl alcohol; tetrahydrofuran / 8 h / 25 °C
4: toluene-4-sulfonic acid / toluene / 25 - 120 °C
5: hydrogen / palladium on carbon / ethanol / 25 °C / Inert atmosphere
6: water; lithium chloride / dimethyl sulfoxide / 16 h / 90 °C
7: cerium(III) chloride heptahydrate / 3 h / 100 °C
8: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C
9: dipyridinium dichromate / dichloromethane / 25 °C
10: tetrahydrofuran / 2 h / 0 °C
With
sodium periodate; osmium(VIII) oxide; dipyridinium dichromate; cerium(III) chloride heptahydrate; water; hydrogen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; lithium chloride;
bis-triphenylphosphine-palladium(II) chloride; palladium on carbon; toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; toluene; tert-butyl alcohol;
