7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde

Base Information

Chemical Name:7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde
CAS No.:1312605-93-8
Molecular Formula:C₁₆H₁₁FN₂O₃S
Molecular Weight:330.339
Hs Code.:

Synonyms:7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde

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Chemical Property of 7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde

Chemical Property:

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Technology Process of 7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde

There total 12 articles about 7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312605-92-7
(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol

: 1312605-93-8
7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde

Guidance literature:: With dipyridinium dichromate; In dichloromethane; at 25 ℃;

Reference yield:

: 1312605-88-1
5-fluoro-3-nitro-2-vinylpyridine

: 1312605-93-8
7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; tetrahydrofuran / 6 h / 25 °C

2: sodium periodate; water / tert-butyl alcohol; tetrahydrofuran / 8 h / 25 °C

3: toluene-4-sulfonic acid / toluene / 25 - 120 °C

4: hydrogen / palladium on carbon / ethanol / 25 °C / Inert atmosphere

5: water; lithium chloride / dimethyl sulfoxide / 16 h / 90 °C

6: cerium(III) chloride heptahydrate / 3 h / 100 °C

7: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C

8: dipyridinium dichromate / dichloromethane / 25 °C

With sodium periodate; osmium(VIII) oxide; dipyridinium dichromate; cerium(III) chloride heptahydrate; water; hydrogen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; lithium chloride; palladium on carbon; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; toluene; tert-butyl alcohol;

Reference yield:

: 652160-72-0
2-bromo-5-fluoro-3-nitropyridine

: 1312605-93-8
7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere

2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; tetrahydrofuran / 6 h / 25 °C

3: sodium periodate; water / tert-butyl alcohol; tetrahydrofuran / 8 h / 25 °C

4: toluene-4-sulfonic acid / toluene / 25 - 120 °C

5: hydrogen / palladium on carbon / ethanol / 25 °C / Inert atmosphere

6: water; lithium chloride / dimethyl sulfoxide / 16 h / 90 °C

7: cerium(III) chloride heptahydrate / 3 h / 100 °C

8: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C

9: dipyridinium dichromate / dichloromethane / 25 °C

With sodium periodate; osmium(VIII) oxide; dipyridinium dichromate; cerium(III) chloride heptahydrate; water; hydrogen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium on carbon; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; toluene; tert-butyl alcohol;