4-(4-Chlorophenyl)-3,3-dimethyl-2-azetidinone

Base Information

Chemical Name:4-(4-Chlorophenyl)-3,3-dimethyl-2-azetidinone
CAS No.:180264-45-3
Molecular Formula:C₁₁H₁₂ClNO
Molecular Weight:209.675
Hs Code.:
DSSTox Substance ID:DTXSID001253680

Synonyms:4-(4-chlorophenyl)-3,3-dimethyl-2-azetidinone;180264-45-3;DTXSID001253680

Suppliers and Price of 4-(4-Chlorophenyl)-3,3-dimethyl-2-azetidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-(4-Chlorophenyl)-3,3-dimethyl-2-azetidinone

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:209.0607417
Heavy Atom Count:14
Complexity:244

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(C(NC1=O)C2=CC=C(C=C2)Cl)C

Technology Process of 4-(4-Chlorophenyl)-3,3-dimethyl-2-azetidinone

There total 2 articles about 4-(4-Chlorophenyl)-3,3-dimethyl-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 180264-45-3
4-(4-chlorophenyl)-3,3-dimethyl-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 20 min, 2.) THF

2: 1.) LDA / 1.) THF, hexane, -70 deg C, 60 min, 2.) THF, hexane, a) -70 deg C, 60 min, b) RT, 18 h

With n-butyllithium; lithium diisopropyl amide;
DOI:10.1021/jm980126v

Reference yield:

: 85654-07-5
N-(4-chlorobenzylidene)-N-(1,1,1-trimethylsilyl)amine

: 97-62-1
Ethyl isobutyrate

: 180264-45-3
4-(4-chlorophenyl)-3,3-dimethyl-2-azetidinone

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, -70 deg C, 60 min, 2.) THF, hexane, a) -70 deg C, 60 min, b) RT, 18 h;
DOI:10.1021/jm980126v