Methyprylon

Base Information

• Chemical Name: Methyprylon
• CAS No.: 125-64-4
• Molecular Formula: C₁₀H₁₇NO₂
• Molecular Weight: 183.25
• European Community (EC) Number: 204-745-4
• NSC Number: 30442
• UNII: CUT48I42ON,P66Z3UR32T,X66M7YN35V
• DSSTox Substance ID: DTXSID7023306
• Nikkaji Number: J41.174D,J82.012A,J82.013J
• Wikipedia: Methyprylon
• Wikidata: Q409558
• NCI Thesaurus Code: C66122
• Pharos Ligand ID: 7ADL4WJX6Q54
• Metabolomics Workbench ID: 43336
• ChEMBL ID: CHEMBL1200790
• Mol file: 125-64-4.mol

Synonyms:methprylon;methyprylon;Noludar

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Chemical Property of Methyprylon

Chemical Property:

• Vapor Pressure: 8.93E-05mmHg at 25°C
• Melting Point: 74-77°
• Refractive Index: 1.4730 (estimate)
• Boiling Point: 339.9°Cat760mmHg
• PKA: 12.11±0.70(Predicted)
• Flash Point: 143.1°C
• PSA: 46.17000
• Density: 0.969g/cm³
• LogP: 1.45660
• Water Solubility.: 76g/L(25 oC)
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 183.125928785
• Heavy Atom Count: 13
• Complexity: 231

Purity/Quality:

Safty Information:

• Pictogram(s): Abuse may cause addiction.
• Hazard Codes: Abuse may cause addiction.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1(C(=O)C(CNC1=O)C)CC
• Uses: Medicine (sedative, hypnotic).
• Therapeutic Function: Sedative, Hypnotic

Technology Process of Methyprylon

There total 5 articles about Methyprylon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ methyprylon (125-64-4,30590-00-2,30590-01-3)

Guidance literature:

With methanol; nickel; at 120 ℃; under 73550.8 Torr; (+-)-3,3-diethyl-5-methyl-piperidine-2,4-dione; Hydrogenation;

Reference yield:

→ methyprylon (125-64-4,30590-00-2,30590-01-3)

Guidance literature:

With acetone; at 0 ℃; (+)-3,3-diethyl-5-methyl-piperidine-2,4-dione; Gewinnung durch fraktionierte Kristallisation;

DOI:10.1002/hlca.19560390526

Reference yield:

3,3-diethyl-5-hydroxymethyl-1H-pyridine-2,4-dione (20096-03-1) → methyprylon (125-64-4,30590-00-2,30590-01-3)

Guidance literature:

With methanol; palladium on activated charcoal; (+-)-3,3-diethyl-5-methyl-piperidine-2,4-dione; Hydrogenation;

DOI:10.1002/hlca.19540370630

upstream raw materials:

3,3-diethyl-5-hydroxymethyl-1H-pyridine-2,4-dione

ethanol

acetic acid

3,3-diethyl-2,4(1H,3H)-pyridinedione