(+/-)-1-Hydroxy-1-(2-methoxy-phenyl)-1.2.3.4-tetrahydro-naphthalin

Base Information

• Chemical Name: (+/-)-1-Hydroxy-1-(2-methoxy-phenyl)-1.2.3.4-tetrahydro-naphthalin
• CAS No.: 408313-37-1
• Molecular Formula: C₁₇H₁₈O₂
• Molecular Weight: 254.329
• Mol file: 408313-37-1.mol

Synonyms:(+/-)-1-Hydroxy-1-(2-methoxy-phenyl)-1.2.3.4-tetrahydro-naphthalin

Chemical Property of (+/-)-1-Hydroxy-1-(2-methoxy-phenyl)-1.2.3.4-tetrahydro-naphthalin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+/-)-1-Hydroxy-1-(2-methoxy-phenyl)-1.2.3.4-tetrahydro-naphthalin

There total 2 articles about (+/-)-1-Hydroxy-1-(2-methoxy-phenyl)-1.2.3.4-tetrahydro-naphthalin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxyphenyl magnesium bromide (13139-86-1) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → (+/-)-1-Hydroxy-1-(2-methoxy-phenyl)-1.2.3.4-tetrahydro-naphthalin (408313-37-1)

Guidance literature:

With diethyl ether; benzene; at 20 ℃;

DOI:10.1021/ja01182a018

Reference yield:

2-methoxyphenylmagnesium bromide (16750-63-3) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → (+/-)-1-Hydroxy-1-(2-methoxy-phenyl)-1.2.3.4-tetrahydro-naphthalin (408313-37-1)

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1002/anie.201408929

Reference yield:

(+/-)-1-Hydroxy-1-(2-methoxy-phenyl)-1.2.3.4-tetrahydro-naphthalin (408313-37-1) → benzo[b]naphtho[1,8-de]pyran (200-23-7)

Guidance literature:

Multi-step reaction with 4 steps

2: palladium/charcoal / 280 - 320 °C

3: concentrated aqueous HBr; glacial acetic acid

4: palladium/charcoal / 340 °C

With palladium on activated charcoal; hydrogen bromide; acetic acid;

DOI:10.1021/ja01182a018

upstream raw materials:

4-methoxyphenyl magnesium bromide

3,4-dihydronaphthalene-1(2H)-one

2-methoxyphenylmagnesium bromide

Downstream raw materials:

2-(3,4-dihydro-[1]naphthyl)-anisole

1-(2-methoxyphenyl)naphthalene

1-(2′-hydroxyphenyl)naphthalene

benzo[b]naphtho[1,8-de]pyran