(1S,2S,(S)S)-1-(1-naphthyl)-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane

Base Information

Chemical Name:(1S,2S,(S)S)-1-(1-naphthyl)-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane
CAS No.:738617-40-8
Molecular Formula:C₂₉H₃₂O₂SSi
Molecular Weight:472.723
Hs Code.:

Synonyms:(1S,2S,(S)S)-1-(1-naphthyl)-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane

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Chemical Property of (1S,2S,(S)S)-1-(1-naphthyl)-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane

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Technology Process of (1S,2S,(S)S)-1-(1-naphthyl)-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane

There total 3 articles about (1S,2S,(S)S)-1-(1-naphthyl)-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 75-77-4
chloro-trimethyl-silane

: 738617-17-9
(1S,2S,(S)S)-1-(1-naphthyl)-2-[2-(p-tolylsulfinyl)phenyl]-1-propanol

: 738617-40-8
(1S,2S,(S)S)-1-(1-naphthyl)-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.tet.2004.04.051

Reference yield:

: 66-77-3
1-naphthaldehyde

: 738617-40-8
(1S,2S,(S)S)-1-(1-naphthyl)-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi; i-Pr₂NH / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 73 percent / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.1: 59 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

With 2,6-dimethylpyridine; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2004.04.051

Reference yield:

: 302934-10-7
(S)-1-ethyl-2-(p-tolylsulfinyl)benzene

: 738617-40-8
(1S,2S,(S)S)-1-(1-naphthyl)-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi; i-Pr₂NH / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 73 percent / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.1: 59 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

With 2,6-dimethylpyridine; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2004.04.051