(R)-methyl-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoate

Base Information

Chemical Name:(R)-methyl-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoate
CAS No.:1371608-97-7
Molecular Formula:C₁₂H₁₃ClN₂O₃
Molecular Weight:268.7
Hs Code.:

Synonyms:(R)-methyl-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoate

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Technology Process of (R)-methyl-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoate

There total 1 articles about (R)-methyl-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 684-93-5
1-methyl-1-nitrosourea

: 1182367-37-8
(R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid

: 1371608-97-7
(R)-methyl-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoate

Guidance literature:: 1-methyl-1-nitrosourea; With potassium hydroxide; In diethyl ether;

(R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid; In tetrahydrofuran; diethyl ether; at 0 ℃; for 3h;

Reference yield: 55.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1371608-97-7
(R)-methyl-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoate

: 1371608-98-8
(R)-methyl-3-(3-chloro-4-cyano-2-methylphenyl)-2-oxooxazolidine-4-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1371608-97-7
(R)-methyl-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoate

: 1371608-99-9
(S)-2-chloro-4-(4-(hydroxymethyl)-2-oxooxazolidin-3-yl)-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / -78 - 20 °C / Inert atmosphere

2: ethanol; sodium tetrahydroborate / 4 h / 0 - 20 °C

With sodium tetrahydroborate; ethanol; N-ethyl-N,N-diisopropylamine; In dichloromethane;