(R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid

Base Information

• Chemical Name: (R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid
• CAS No.: 1182367-37-8
• Molecular Formula: C₁₁H₁₁ClN₂O₃
• Molecular Weight: 254.673
• Mol file: 1182367-37-8.mol

Synonyms:(R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid

Chemical Property of (R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid

There total 1 articles about (R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

2-chloro-4-fluoro-3-methylbenzonitrile (796600-15-2) + D-Serine (312-84-5,83245-15-2) → (R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid (1182367-37-8)

Guidance literature:

2-chloro-4-fluoro-3-methylbenzonitrile; D-Serine; With potassium carbonate; In dimethyl sulfoxide; at 20 - 75 ℃;

With citric acid; In water; dimethyl sulfoxide; at 20 ℃; Product distribution / selectivity;

Reference yield: 93.0%

4-cyanobenzohydrazide (43038-36-4) + (R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid (1182367-37-8) → (R)-N'-(2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoyl)-4-cyanobenzohydrazide (1182368-67-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at -15 - 20 ℃;

Reference yield:

(R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid (1182367-37-8) + benzoic acid hydrazide (613-94-5) → (R)-N'-(2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoyl)benzohydrazide (1182367-38-9)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;

upstream raw materials:

2-chloro-4-fluoro-3-methylbenzonitrile

D-Serine

Downstream raw materials:

(R)-N'-(2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoyl)benzohydrazide

(R)-N'-(2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoyl)-4-cyanobenzohydrazide

(R)-methyl-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoate

(R)-methyl-3-(3-chloro-4-cyano-2-methylphenyl)-2-oxooxazolidine-4-carboxylate