5-(tert-butyl-dimethyl-silanyloxy)-isophthalic acid bis-(4-trifluoromethyl-phenyl) ester

Base Information

• Chemical Name: 5-(tert-butyl-dimethyl-silanyloxy)-isophthalic acid bis-(4-trifluoromethyl-phenyl) ester
• CAS No.: 438526-12-6
• Molecular Formula: C₂₈H₂₆F₆O₅Si
• Molecular Weight: 584.587
• Mol file: 438526-12-6.mol

Synonyms:5-(tert-butyl-dimethyl-silanyloxy)-isophthalic acid bis-(4-trifluoromethyl-phenyl) ester

Chemical Property of 5-(tert-butyl-dimethyl-silanyloxy)-isophthalic acid bis-(4-trifluoromethyl-phenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(tert-butyl-dimethyl-silanyloxy)-isophthalic acid bis-(4-trifluoromethyl-phenyl) ester

There total 4 articles about 5-(tert-butyl-dimethyl-silanyloxy)-isophthalic acid bis-(4-trifluoromethyl-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-hydroxybenzotrifluoride (402-45-9) + 5-(tert-butyldimethylsilyloxy)isophthalic acid (219965-98-7) → 5-(tert-butyl-dimethyl-silanyloxy)-isophthalic acid bis-(4-trifluoromethyl-phenyl) ester (438526-12-6)

Guidance literature:

With bis-2-propyl carbonate; 4-(dimethylamino)pyridinium tosylate; In dichloromethane;

DOI:10.1021/ja020071t

Reference yield:

5-Hydroxyisophthalic acid (618-83-7) → 5-(tert-butyl-dimethyl-silanyloxy)-isophthalic acid bis-(4-trifluoromethyl-phenyl) ester (438526-12-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / imidazole / dimethylformamide / 20 °C

2: 78 percent / aq. AcOH / tetrahydrofuran / 24 h

3: 95 percent / DPTS; DIPC / CH₂Cl₂

With 1H-imidazole; bis-2-propyl carbonate; acetic acid; 4-(dimethylamino)pyridinium tosylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja020071t

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 5-(tert-butyl-dimethyl-silanyloxy)-isophthalic acid bis-(4-trifluoromethyl-phenyl) ester (438526-12-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / imidazole / dimethylformamide / 20 °C

2: 78 percent / aq. AcOH / tetrahydrofuran / 24 h

3: 95 percent / DPTS; DIPC / CH₂Cl₂

With 1H-imidazole; bis-2-propyl carbonate; acetic acid; 4-(dimethylamino)pyridinium tosylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja020071t

upstream raw materials:

4-hydroxybenzotrifluoride

5-(tert-butyldimethylsilyloxy)isophthalic acid

5-Hydroxyisophthalic acid

tert-butyldimethylsilyl chloride

Downstream raw materials:

5-hydroxy-isophthalic acid bis-(4-trifluoromethyl-phenyl) ester