4-[3-[4(2-Methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

Base Information

Chemical Name:4-[3-[4(2-Methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde
CAS No.:179420-48-5
Molecular Formula:C₂₂H₂₂N₂O₂S
Molecular Weight:378.495
Hs Code.:

Synonyms:4-[3-[4(2-Methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

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Chemical Property of 4-[3-[4(2-Methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

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Technology Process of 4-[3-[4(2-Methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

There total 7 articles about 4-[3-[4(2-Methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 179421-20-6
[4-[3-[4-(2-Methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro2H-pyran-4yl]methanol

: 179420-48-5
4-[3-[4(2-Methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 - -20 ℃; for 2.5h;
DOI:10.1016/j.bmcl.2005.03.041

Reference yield:

: 179421-20-6
[4-[3-[4-(2-Methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro2H-pyran-4yl]methanol

: swern reagent

: 79-37-8
oxalyl dichloride

: 179420-48-5
4-[3-[4(2-Methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

Guidance literature:: With triethylamine; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 179421-14-8
4-cyano-4-(3-iodophenyl)-3,4,5,6-tetrahydro-2H-pyran

: 179420-48-5
4-[3-[4(2-Methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: KOH; t-BuOH / 4 h / 80 °C

2: 35 percent / HCl / Heating

3: 69 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

4: 77 percent / (COCl)2; DMSO / CH₂Cl₂ / 2.5 h / -78 - -20 °C

With hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; tert-butyl alcohol; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.03.041