2-(2,5-diethyl-3,4,6-trifluorophenyl)-4,4-dimethyl-5H-1,3-oxazole

Base Information

Chemical Name:2-(2,5-diethyl-3,4,6-trifluorophenyl)-4,4-dimethyl-5H-1,3-oxazole
CAS No.:865246-11-3
Molecular Formula:C₁₅H₁₈F₃NO
Molecular Weight:285.309
Hs Code.:
DSSTox Substance ID:DTXSID501156047
Nikkaji Number:J2.209.207C

Synonyms:DTXSID501156047;865246-11-3;2-(2,5-Diethyl-3,4,6-trifluorophenyl)-4,5-dihydro-4,4-dimethyloxazole

Suppliers and Price of 2-(2,5-diethyl-3,4,6-trifluorophenyl)-4,4-dimethyl-5H-1,3-oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2,5-diethyl-3,4,6-trifluorophenyl)-4,4-dimethyl-5H-1,3-oxazole

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:285.13404868
Heavy Atom Count:20
Complexity:385

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=C(C(=C(C(=C1F)F)CC)F)C2=NC(CO2)(C)C

Technology Process of 2-(2,5-diethyl-3,4,6-trifluorophenyl)-4,4-dimethyl-5H-1,3-oxazole

There total 2 articles about 2-(2,5-diethyl-3,4,6-trifluorophenyl)-4,4-dimethyl-5H-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 865246-08-8
2-(3-ethyl-2,4,5-trifluoro-phenyl)-4,4-dimethyl-oxazoline

: 75-03-6
ethyl iodide

: 865246-11-3
2-(3,6-diethyl-2,4,5-trifluoro-phenyl)-4,4-dimethyl-oxazoline

Guidance literature:: 2-(3-ethyl-2,4,5-trifluoro-phenyl)-4,4-dimethyl-oxazoline; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

ethyl iodide; at -78 - 20 ℃;
DOI:10.1016/j.tet.2005.06.078

Reference yield:

: 125290-72-4
2-(2,4,5-trifluorophenyl)-4,4-dimethyl-2-oxazoline

: 865246-11-3
2-(3,6-diethyl-2,4,5-trifluoro-phenyl)-4,4-dimethyl-oxazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 96 percent / various solvent(s) / -78 - 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 76 percent / various solvent(s) / -78 - 20 °C

With lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2005.06.078