1-{2-[3-(4-chlorophenyl)-[1,2,4]oxadiazol-5-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)-piperidine hydrochloride

Base Information

Chemical Name:1-{2-[3-(4-chlorophenyl)-[1,2,4]oxadiazol-5-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)-piperidine hydrochloride
CAS No.:1609575-56-5
Molecular Formula:C₂₄H₂₂ClF₆N₃O*ClH
Molecular Weight:554.363
Hs Code.:

Synonyms:1-{2-[3-(4-chlorophenyl)-[1,2,4]oxadiazol-5-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)-piperidine hydrochloride

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Chemical Property of 1-{2-[3-(4-chlorophenyl)-[1,2,4]oxadiazol-5-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)-piperidine hydrochloride

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Technology Process of 1-{2-[3-(4-chlorophenyl)-[1,2,4]oxadiazol-5-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)-piperidine hydrochloride

There total 6 articles about 1-{2-[3-(4-chlorophenyl)-[1,2,4]oxadiazol-5-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)-piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1609575-73-6
N-((4-chlorophenyl)-(hydroxyimino)methyl)-4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)phenyl)piperidin-1-yl)methyl)butanamide

: 1609575-56-5
1-{2-[3-(4-chlorophenyl)-[1,2,4]oxadiazol-5-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)-piperidine hydrochloride

Guidance literature:: N-((4-chlorophenyl)-(hydroxyimino)methyl)-4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)phenyl)piperidin-1-yl)methyl)butanamide; In N,N-dimethyl-formamide; at 120 ℃; for 3h; Sealed tube;

With hydrogenchloride; In 1,4-dioxane; hexane;

Reference yield:

: 328-62-1
4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

: 1609575-56-5
1-{2-[3-(4-chlorophenyl)-[1,2,4]oxadiazol-5-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)-piperidine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / tetrahydrofuran; water / 0.33 h / 0 °C

1.2: 0.5 h

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

3.1: sodium hydroxide; ethanol / 0.5 h / 90 °C

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 4 h / 20 °C

5.1: N,N-dimethyl-formamide / 3 h / 120 °C / Sealed tube

With ethanol; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 623-03-0
4-Cyanochlorobenzene

: 1609575-56-5
1-{2-[3-(4-chlorophenyl)-[1,2,4]oxadiazol-5-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)-piperidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / 6 h / 100 °C

2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 4 h / 20 °C

3.1: N,N-dimethyl-formamide / 3 h / 120 °C / Sealed tube

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; N,N-dimethyl-formamide;