5-bromo-2-(2-(4-(thiophen-2-yl)benzylidene)hydrazinyl)pyridine

Base Information

• Chemical Name: 5-bromo-2-(2-(4-(thiophen-2-yl)benzylidene)hydrazinyl)pyridine
• CAS No.: 1293385-64-4
• Molecular Formula: C₁₆H₁₂BrN₃S
• Molecular Weight: 358.261
• Mol file: 1293385-64-4.mol

Synonyms:5-bromo-2-(2-(4-(thiophen-2-yl)benzylidene)hydrazinyl)pyridine

Chemical Property of 5-bromo-2-(2-(4-(thiophen-2-yl)benzylidene)hydrazinyl)pyridine

Chemical Property:

Purity/Quality:

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Technology Process of 5-bromo-2-(2-(4-(thiophen-2-yl)benzylidene)hydrazinyl)pyridine

There total 1 articles about 5-bromo-2-(2-(4-(thiophen-2-yl)benzylidene)hydrazinyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-bromo-2-hydrazinylpyridine (77992-44-0) + 4-(2-thienyl)benzaldehyde (107834-03-7) → 5-bromo-2-(2-(4-(thiophen-2-yl)benzylidene)hydrazinyl)pyridine (1293385-64-4)

Guidance literature:

With pyridine; at 80 ℃; for 3.5h;

DOI:10.1021/ja2005175

Reference yield: 90.0%

5-bromo-2-(2-(4-(thiophen-2-yl)benzylidene)hydrazinyl)pyridine (1293385-64-4) → 6-bromo-3,3-difluoro-2-(4-(thiophen-2-yl)benzylidene)-2,3-dihydro-[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide (1293979-76-6)

Guidance literature:

With boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 20 - 90 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ja2005175

Reference yield: 90.0%

C4H3SC6H4CHN2C5H3NBrH (1293385-64-4) + trifluoroborane diethyl ether (109-63-7) → 6-bromo-3,3-difluoro-2-(4-(thiophen-2-yl)benzylidene)-2,3-dihydro-[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide (1293979-76-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; B-compound was added dropwise to a mixt. of hydrazole and bicyclo-compound in anhyd. toluene at room temp., heated at 90°C for 3 h under Ar atm.; the mixt. was quenched with water, extd. with CH2Cl2, the organic layerswere washed with water (3 times), dried over anhyd. Na2SO4, evapd. unde r reduced pressure, silica gel column chromy. (CH3OH/CH2Cl2 (0-1%));

DOI:10.1021/ja2005175

upstream raw materials:

5-bromo-2-hydrazinylpyridine

4-(2-thienyl)benzaldehyde

Downstream raw materials:

6-bromo-3,3-difluoro-2-(4-(thiophen-2-yl)benzylidene)-2,3-dihydro-[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide