1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate

Base Information

Chemical Name:1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate
CAS No.:1059129-36-0
Molecular Formula:C₂HF₃O₂*C₁₈H₁₇ClN₂O₂S
Molecular Weight:474.888
Hs Code.:

Synonyms:1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate

Suppliers and Price of 1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate

There total 5 articles about 1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1059131-40-6
tert-butyl 1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate

: 25300-37-2
2-chloro-6-methylbenzenesulfonyl chloride

: 76-05-1
trifluoroacetic acid

: 1059129-36-0
1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate

Guidance literature:: tert-butyl 1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate; With sodium hydride; In acetonitrile; at 20 ℃; for 1.5h;

2-chloro-6-methylbenzenesulfonyl chloride; In acetonitrile; for 3h;

trifluoroacetic acid; In acetonitrile; for 2 - 16h;

Reference yield:

: 39830-66-5
methyl 1H-indole-4-carboxylate

: 1059129-36-0
1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-tert-Butylcatechol / xylene / 6 h / Heating / reflux

2.1: hydrogenchloride; zinc / methanol; water / 2 h / Heating / reflux

3.1: trichlorophosphate / 0.25 h / 20 °C

3.2: 1 h / 0 - 20 °C

4.1: dichloromethane / 20 °C

5.1: sodium hydride / acetonitrile / 1.5 h / 20 °C

5.2: 3 h

5.3: 2 - 16 h

With hydrogenchloride; 4-tert-Butylcatechol; sodium hydride; zinc; trichlorophosphate; In methanol; dichloromethane; water; acetonitrile; xylene;

Reference yield:

: 38073-24-4
3,4,5,6-tetrahydro-1H-azepino<5,4,3-cd>indole

: 1059129-36-0
1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 20 °C

2.1: sodium hydride / acetonitrile / 1.5 h / 20 °C

2.2: 3 h

2.3: 2 - 16 h

With sodium hydride; In dichloromethane; acetonitrile;