Technology Process of 1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate
There total 5 articles about 1-[(2-chloro-6-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole trifluoroacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate;
With
sodium hydride;
In
acetonitrile;
at 20 ℃;
for 1.5h;
2-chloro-6-methylbenzenesulfonyl chloride;
In
acetonitrile;
for 3h;
trifluoroacetic acid;
In
acetonitrile;
for 2 - 16h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 4-tert-Butylcatechol / xylene / 6 h / Heating / reflux
2.1: hydrogenchloride; zinc / methanol; water / 2 h / Heating / reflux
3.1: trichlorophosphate / 0.25 h / 20 °C
3.2: 1 h / 0 - 20 °C
4.1: dichloromethane / 20 °C
5.1: sodium hydride / acetonitrile / 1.5 h / 20 °C
5.2: 3 h
5.3: 2 - 16 h
With
hydrogenchloride; 4-tert-Butylcatechol; sodium hydride; zinc; trichlorophosphate;
In
methanol; dichloromethane; water; acetonitrile; xylene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dichloromethane / 20 °C
2.1: sodium hydride / acetonitrile / 1.5 h / 20 °C
2.2: 3 h
2.3: 2 - 16 h
With
sodium hydride;
In
dichloromethane; acetonitrile;