diethyl (1-dimethyl[phenyl]silylvinyl)(3-methoxybenzyl)malonate

Base Information

• Chemical Name: diethyl (1-dimethyl[phenyl]silylvinyl)(3-methoxybenzyl)malonate
• CAS No.: 861391-99-3
• Molecular Formula: C₂₅H₃₂O₅Si
• Molecular Weight: 440.612
• Mol file: 861391-99-3.mol

Synonyms:diethyl (1-dimethyl[phenyl]silylvinyl)(3-methoxybenzyl)malonate

Chemical Property of diethyl (1-dimethyl[phenyl]silylvinyl)(3-methoxybenzyl)malonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of diethyl (1-dimethyl[phenyl]silylvinyl)(3-methoxybenzyl)malonate

There total 1 articles about diethyl (1-dimethyl[phenyl]silylvinyl)(3-methoxybenzyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

trimethylsulphonium iodide (2181-42-2) + ethyl 2-ethoxycarbonyl-3-dimethyl(phenyl)silyl-2-propenoate (130247-53-9) + 1-bromomethyl-3-methoxybenzene (874-98-6) → diethyl (1-dimethyl[phenyl]silylvinyl)(3-methoxybenzyl)malonate (861391-99-3)

Guidance literature:

trimethylsulphonium iodide; With sodium methylsulfinylmethanide; In tetrahydrofuran; dimethyl sulfoxide; at -8 ℃; for 0.25h;

ethyl 2-ethoxycarbonyl-3-dimethyl(phenyl)silyl-2-propenoate; In tetrahydrofuran; dimethyl sulfoxide; at -8 - 20 ℃; for 3.25h;

1-bromomethyl-3-methoxybenzene; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 14h;

DOI:10.1039/b509102k

Reference yield: 63.0%

diethyl (1-dimethyl[phenyl]silylvinyl)(3-methoxybenzyl)malonate (861391-99-3) → dimethyl-2-[3,3-diethoxycarbonyl-4-(3-methoxyphenyl)-1-butenyl]silanol (861392-00-9) + 1,1,3,3-tetramethyl-1,3-di[3,3-diethoxycarbonyl-4-(3-methoxyphenyl)-1-butenyl]disiloxane (861392-01-0)

Guidance literature:

diethyl (1-dimethyl[phenyl]silylvinyl)(3-methoxybenzyl)malonate; With trifluorormethanesulfonic acid; In dichloromethane; at -10 ℃; for 0.166667h;

With ammonium hydroxide; In dichloromethane; Further stages.;

DOI:10.1002/ejoc.200700440

Reference yield:

diethyl (1-dimethyl[phenyl]silylvinyl)(3-methoxybenzyl)malonate (861391-99-3) + para-iodoanisole (696-62-8) → ethyl (E)-2-ethoxycarbonyl-2-(3-methoxybenzyl)-4-(4-methoxyphenyl)-3-butenoate

Guidance literature:

Multistep reaction.;

DOI:10.1002/ejoc.200700440

upstream raw materials:

trimethylsulphonium iodide

ethyl 2-ethoxycarbonyl-3-dimethyl(phenyl)silyl-2-propenoate

1-bromomethyl-3-methoxybenzene

Downstream raw materials:

dimethyl-2-[3,3-diethoxycarbonyl-4-(3-methoxyphenyl)-1-butenyl]silanol

1,1,3,3-tetramethyl-1,3-di[3,3-diethoxycarbonyl-4-(3-methoxyphenyl)-1-butenyl]disiloxane