8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Base Information

• Chemical Name: 8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate
• CAS No.: 1259038-91-9
• Molecular Formula: C₃₂H₄₅N₇O₄
• Molecular Weight: 591.754
• Mol file: 1259038-91-9.mol

Synonyms:8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Chemical Property of 8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

There total 1 articles about 8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzaldehyde (937074-60-7) + 3-ethoxycarbonyl-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester (203934-60-5) → 8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate (1259038-91-9)

Guidance literature:

4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzaldehyde; 3-ethoxycarbonyl-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; With acetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate (1259038-91-9) → Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3-carboxylate (1259038-92-0)

Guidance literature:

8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate; With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃; for 3h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate (1259038-91-9) → (3R)-2-(4-{[bis(1H-imidazol-2-ylmethyl)amino] methyl}benzyl)-8-isobutyl-2,8-diazaspiro[4.5]decane-3-carboxylic acid (1259038-99-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; ethanol / 3 h / 20 °C / Inert atmosphere

2: acetic acid; sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3: sodium hydroxide; water / ethanol / 2 h / 80 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; acetic acid; sodium hydroxide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzaldehyde

3-ethoxycarbonyl-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

Downstream raw materials:

(3R)-2-(4-{[bis(1H-imidazol-2-ylmethyl)amino] methyl}benzyl)-8-isobutyl-2,8-diazaspiro[4.5]decane-3-carboxylic acid

ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino] methyl}benzyl)-8-isobutyl-2,8-diazaspiro[4.5]decane-3-carboxylate

Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3-carboxylate

Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decane-3-carboxylate