Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3-carboxylate

Base Information

• Chemical Name: Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3-carboxylate
• CAS No.: 1259038-92-0
• Molecular Formula: C₂₇H₃₇N₇O₂
• Molecular Weight: 491.636
• Mol file: 1259038-92-0.mol

Synonyms:Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3-carboxylate

Chemical Property of Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3-carboxylate

There total 3 articles about Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate (1259038-91-9) → Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3-carboxylate (1259038-92-0)

Guidance literature:

8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate; With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃; for 3h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzaldehyde (937074-60-7) → Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3-carboxylate (1259038-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; ethanol / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; acetic acid; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

3-ethoxycarbonyl-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester (203934-60-5) → Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3-carboxylate (1259038-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; ethanol / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; acetic acid; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzaldehyde

3-ethoxycarbonyl-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

8-tert-butyl 3-ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Downstream raw materials:

Ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decane-3-carboxylate

(3R)-2-(4-{[bis(1H-imidazol-2-ylmethyl)amino] methyl}benzyl)-8-isobutyl-2,8-diazaspiro[4.5]decane-3-carboxylic acid

ethyl 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino] methyl}benzyl)-8-isobutyl-2,8-diazaspiro[4.5]decane-3-carboxylate