4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid hydrazide

Base Information

Chemical Name:4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid hydrazide
CAS No.:1401728-88-8
Molecular Formula:C₁₈H₂₁N₅O
Molecular Weight:323.398
Hs Code.:

Synonyms:4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid hydrazide

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Chemical Property of 4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid hydrazide

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Technology Process of 4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid hydrazide

There total 10 articles about 4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1401728-87-7
4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid methyl ester

: 1401728-88-8
4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid hydrazide

Guidance literature:: With hydrazine hydrate; In methanol; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/acs.jmedchem.6b01703

Reference yield:

: 1401728-86-6
4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoic acid

: 1401728-88-8
4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: chloro-trimethyl-silane / 16 h / 20 °C

2: hydrazine hydrate / methanol / 3 h / 80 °C

With chloro-trimethyl-silane; hydrazine hydrate; In methanol;

Reference yield:

: 33279-01-5
3-oxo-pentanenitrile

: 1401728-88-8
4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid hydrazide

Guidance literature:: Multi-step reaction with 6 steps

1: L-proline / ethanol / 16 h / 22 °C

2: hydrogen; palladium 10% on activated carbon / methanol; acetonitrile / 2 h / 25 °C / 2585.81 Torr

3: hydrazine / methanol / 3 h / 65 °C

4: acetic acid; hydrogenchloride; water / 43 h / 110 °C

5: chloro-trimethyl-silane / 16 h / 20 °C

6: hydrazine hydrate / methanol / 3 h / 80 °C

With hydrogenchloride; chloro-trimethyl-silane; palladium 10% on activated carbon; water; hydrogen; hydrazine hydrate; acetic acid; L-proline; hydrazine; In methanol; ethanol; acetonitrile;