5-(2-hydroxy-4-nitroanilinocarbonyl)-2-methyl-1-(tetrahydropyran-4-yl)benzimidazole

Base Information

Chemical Name:5-(2-hydroxy-4-nitroanilinocarbonyl)-2-methyl-1-(tetrahydropyran-4-yl)benzimidazole
CAS No.:1256968-48-5
Molecular Formula:C₂₀H₂₀N₄O₅
Molecular Weight:396.403
Hs Code.:

Synonyms:5-(2-hydroxy-4-nitroanilinocarbonyl)-2-methyl-1-(tetrahydropyran-4-yl)benzimidazole

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Chemical Property of 5-(2-hydroxy-4-nitroanilinocarbonyl)-2-methyl-1-(tetrahydropyran-4-yl)benzimidazole

Chemical Property:

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Technology Process of 5-(2-hydroxy-4-nitroanilinocarbonyl)-2-methyl-1-(tetrahydropyran-4-yl)benzimidazole

There total 6 articles about 5-(2-hydroxy-4-nitroanilinocarbonyl)-2-methyl-1-(tetrahydropyran-4-yl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256969-33-1
2-methyl-1-(tetrahydropyran-4-yl)benzimidazole-5-carboxylic acid chloride hydrochloride

: 99-57-0
2-hydroxy-5-nitroaniline

: 1256968-48-5
5-(2-hydroxy-4-nitroanilinocarbonyl)-2-methyl-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 38041-19-9
4-aminotetrahydropyran

: 1256968-48-5
5-(2-hydroxy-4-nitroanilinocarbonyl)-2-methyl-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / ethanol / 14 h / Reflux

2.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran; methanol / 3 h / 3800.26 Torr

3.1: 1,4-dioxane / 6.08 h / 10 °C / Reflux

3.2: 8 h / Reflux

4.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 7 h / Reflux

5.1: triethylamine / tetrahydrofuran / 3 h / 20 °C

With thionyl chloride; hydrogen; triethylamine; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; toluene;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1256968-48-5
5-(2-hydroxy-4-nitroanilinocarbonyl)-2-methyl-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / ethanol / 14 h / Reflux

2.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran; methanol / 3 h / 3800.26 Torr

3.1: 1,4-dioxane / 6.08 h / 10 °C / Reflux

3.2: 8 h / Reflux

4.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 7 h / Reflux

5.1: triethylamine / tetrahydrofuran / 3 h / 20 °C

With thionyl chloride; hydrogen; triethylamine; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; toluene;