5-(3-(2-chloro-4-fluorophenyl)isoxazolo[4,5-b]pyridin-7-yl)pyrimidin-4-ol

Base Information

Chemical Name:5-(3-(2-chloro-4-fluorophenyl)isoxazolo[4,5-b]pyridin-7-yl)pyrimidin-4-ol
CAS No.:1428882-04-5
Molecular Formula:C₁₆H₈ClFN₄O₂
Molecular Weight:342.717
Hs Code.:

Synonyms:5-(3-(2-chloro-4-fluorophenyl)isoxazolo[4,5-b]pyridin-7-yl)pyrimidin-4-ol

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Chemical Property of 5-(3-(2-chloro-4-fluorophenyl)isoxazolo[4,5-b]pyridin-7-yl)pyrimidin-4-ol

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Technology Process of 5-(3-(2-chloro-4-fluorophenyl)isoxazolo[4,5-b]pyridin-7-yl)pyrimidin-4-ol

There total 6 articles about 5-(3-(2-chloro-4-fluorophenyl)isoxazolo[4,5-b]pyridin-7-yl)pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1428882-03-4
3-(2-chloro-4-fluorophenyl)-7-(pyrimidin-5-yl)isoxazolo[4,5-b]pyridine

: 1428882-04-5
5-(3-(2-chloro-4-fluorophenyl)isoxazolo[4,5-b]pyridin-7-yl)pyrimidin-4-ol

Guidance literature:: With peracetic acid; sulfuric acid; In acetone; for 1.25h; Reflux;

Reference yield:

: 97509-75-6
3-fluoropicolinonitrile

: 1428882-04-5
5-(3-(2-chloro-4-fluorophenyl)isoxazolo[4,5-b]pyridin-7-yl)pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; diisopropylamine; lithium diisopropyl amide / tetrahydrofuran / 0.58 h / -78 °C

1.2: 0.75 h

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 17 h / 85 °C / Inert atmosphere

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C

3.2: -10 - 20 °C

4.1: pyridine; hydroxylamine hydrochloride / 3 h / Reflux

5.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 3 h / 70 °C

6.1: peracetic acid; sulfuric acid / acetone / 1.25 h / Reflux

With pyridine; peracetic acid; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; hydroxylamine hydrochloride; isopropylmagnesium chloride; sodium hydride; caesium carbonate; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 669066-35-7
3-fluoro-4-iodo-2-pyridinecarbonitrile

: 1428882-04-5
5-(3-(2-chloro-4-fluorophenyl)isoxazolo[4,5-b]pyridin-7-yl)pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 17 h / 85 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C

2.2: -10 - 20 °C

3.1: pyridine; hydroxylamine hydrochloride / 3 h / Reflux

4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 3 h / 70 °C

5.1: peracetic acid; sulfuric acid / acetone / 1.25 h / Reflux

With pyridine; peracetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; hydroxylamine hydrochloride; isopropylmagnesium chloride; sodium hydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone;