(Z)-(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone oxime

Base Information

Chemical Name:(Z)-(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone oxime
CAS No.:1428882-02-3
Molecular Formula:C₁₆H₉ClF₂N₄O
Molecular Weight:346.723
Hs Code.:

Synonyms:(Z)-(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone oxime

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Chemical Property of (Z)-(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone oxime

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Technology Process of (Z)-(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone oxime

There total 4 articles about (Z)-(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1428882-01-2
(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone

: 1428882-02-3
(Z)-(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone oxime

Guidance literature:: With pyridine; hydroxylamine hydrochloride; for 3h; Reflux;

Reference yield:

: 97509-75-6
3-fluoropicolinonitrile

: 1428882-02-3
(Z)-(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine; lithium diisopropyl amide / tetrahydrofuran / 0.58 h / -78 °C

1.2: 0.75 h

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 17 h / 85 °C / Inert atmosphere

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C

3.2: -10 - 20 °C

4.1: pyridine; hydroxylamine hydrochloride / 3 h / Reflux

With pyridine; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydroxylamine hydrochloride; isopropylmagnesium chloride; caesium carbonate; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 669066-35-7
3-fluoro-4-iodo-2-pyridinecarbonitrile

: 1428882-02-3
(Z)-(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 17 h / 85 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C

2.2: -10 - 20 °C

3.1: pyridine; hydroxylamine hydrochloride / 3 h / Reflux

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydroxylamine hydrochloride; isopropylmagnesium chloride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water;