(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone

Base Information

Chemical Name:(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone
CAS No.:1428882-01-2
Molecular Formula:C₁₆H₈ClF₂N₃O
Molecular Weight:331.709
Hs Code.:

Synonyms:(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone

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Chemical Property of (2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone

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Technology Process of (2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone

There total 3 articles about (2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.44%

: 1428882-00-1
3-fluoro-4-(pyrimidin-5-yl)picolinonitrile

: 101335-11-9
2-chloro-4-fluoro-1-iodobenzene

: 1428882-01-2
(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone

Guidance literature:: 2-chloro-4-fluoro-1-iodobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; at -10 ℃; for 0.5h;

3-fluoro-4-(pyrimidin-5-yl)picolinonitrile; In tetrahydrofuran; at -10 - 20 ℃;

Reference yield:

: 97509-75-6
3-fluoropicolinonitrile

: 1428882-01-2
(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine; lithium diisopropyl amide / tetrahydrofuran / 0.58 h / -78 °C

1.2: 0.75 h

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 17 h / 85 °C / Inert atmosphere

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C

3.2: -10 - 20 °C

With n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; isopropylmagnesium chloride; caesium carbonate; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 669066-35-7
3-fluoro-4-iodo-2-pyridinecarbonitrile

: 1428882-01-2
(2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 17 h / 85 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C

2.2: -10 - 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; isopropylmagnesium chloride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water;