2-(3-chloro-4-(2-hydroxyethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Base Information

Chemical Name:2-(3-chloro-4-(2-hydroxyethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one
CAS No.:1044870-80-5
Molecular Formula:C₁₈H₁₇ClN₂O₅
Molecular Weight:376.796
Hs Code.:

Synonyms:2-(3-chloro-4-(2-hydroxyethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

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Chemical Property of 2-(3-chloro-4-(2-hydroxyethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

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Technology Process of 2-(3-chloro-4-(2-hydroxyethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

There total 5 articles about 2-(3-chloro-4-(2-hydroxyethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1044872-29-8
4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-3-chloro-benzaldehyde

: 63920-73-0
2-amino-4,6-dimethoxybenzamide

: 1044870-80-5
2-(3-chloro-4-(2-hydroxyethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Guidance literature:: With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; at 150 ℃; for 17h;

Reference yield:

: 21544-81-0
4,6-dimethoxyindoline-2,3-dione

: 1044870-80-5
2-(3-chloro-4-(2-hydroxyethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 70 °C

1.2: 3 h / 20 °C

1.3: 16 h / 20 °C

2.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 17 h / 150 °C / Inert atmosphere

With dihydrogen peroxide; toluene-4-sulfonic acid; sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide; water;

Reference yield:

: 2420-16-8
4-hydroxy-3-chlorobenzaldehyde

: 1044870-80-5
2-(3-chloro-4-(2-hydroxyethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / dimethyl sulfoxide / 17 h / 80 °C

2: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 17 h / 150 °C / Inert atmosphere

With caesium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; dimethyl sulfoxide;