63920-73-0

Basic information

• Product Name: 2-aMino-4,6-diMethoxybenzaMide
• Synonyms: 2-aMino-4,6-diMethoxybenzaMide;Benzamide, 2-amino-4,6-dimethoxy-;4,6-Dimethoxyanthranilamide
• CAS NO: 63920-73-0
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196
• Mol File: 63920-73-0.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 331.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.238±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 15.70±0.50(Predicted)
• CAS DataBase Reference: 2-aMino-4,6-diMethoxybenzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-4,6-diMethoxybenzaMide(63920-73-0)
• EPA Substance Registry System: 2-aMino-4,6-diMethoxybenzaMide(63920-73-0)

Safety Data

• Hazardous Substances Data: 63920-73-0(Hazardous Substances Data)

Usage

General Description

2-Amino-4,6-dimethoxybenzamide is a chemical compound with the molecular formula C9H12N2O3. It belongs to the class of benzamides and contains amine and methoxy functional groups. 2-aMino-4,6-diMethoxybenzaMide has been studied for its potential pharmacological activities, including anti-inflammatory and analgesic effects. It has also been explored for its potential use as a building block in organic synthesis. Additionally, it may have applications in the development of pharmaceuticals and agrochemicals. Overall, 2-amino-4,6-dimethoxybenzamide is a versatile chemical with potential uses in various fields of research and industry.

Upstream product

• 1599437-13-4 N-(2-bromo-3,5-dimethoxybenzene)-2,2,2-trifluoroacetamide 
• 85657-94-9 N-(3,5-dimethoxyphenyl)-2,2,2-trifluoroacetamide 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 1545025-44-2 2-amino-4,6-dimethoxybenzonitrile 
• 1599437-14-5 2-cyano-3,5-dimethoxytrifluoroacetanilide 
• 10272-07-8 3.5-dimethoxyaniline 
• 40891-33-6 3,5-dimethoxyaniline hydrochloride 
• 21544-81-0 4,6-dimethoxyindoline-2,3-dione 
• 21577-57-1 2-amino-4,6-dimethoxybenzoic acid 
• 63920-75-2 1,2-dihydro-5,7-dimethoxy-3,1-benzoxazine-2,4-dione 

Downstream Products

• 1044872-46-9 acetic acid 4-(5,7-dimethoxy-1-methyl-4-oxo-1,4-dihydro-quinazolin-2-yl)-2,6-dimethyl-phenyl ester 
• 1044871-02-4 2-(4-hydroxy-3,5-dimethylphenyl)-5,7-dimethoxy-1-methylquinazolin-4(1H)-one 
• 1044872-71-0 2-(4-benzyloxy-3,5-dimethyl-phenyl)-5-hydroxy-7-methoxy-3H-quinazolin-4-one 
• 1044871-56-8 5-hydroxy-2-(4-hydroxy-3,5-dimethylphenyl)-7-methoxyquinazolin-4(3H)-one 
• 1044870-51-0 2-(4-hydroxy-3-methoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one 
• 1044870-77-0 3-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)propanoic acid 
• 1044870-93-0 N-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)-2-hydroxyacetamide 
• 1044871-09-1 2-(4-hydroxy-3-(2-hydroxyethyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one 
• 1610379-33-3 2-(3-chloro-5-(piperazin-1-yl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one 
• 1044871-58-0 propylcarbamic acid-2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl ester 
• 1044871-46-6 2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one 
• 1044872-68-5 C₁₈H₁₇N₃O₅ 
• 1044871-31-9 2-(4-amino-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one 
• 1610372-43-4 2'-(azetidin-3-yloxy)-5'-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-[1,1'-biphenyl]-4-carbonitrile 

Relevant articles and documents

Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy

Bromodomain-containing protein 4 (BRD4) is an attractive epigenetic target in human cancers. Inhibiting the phosphorylation of BRD4 by casein kinase 2 (CK2) is a potential strategy to overcome drug resistance in cancer therapy. The present study describes the synthesis of multiple BRD4–CK2 dual inhibitors based on rational drug design, structure–activity relationship, and in vitro and in vivo evaluations, and 44e was identified to possess potent and balanced activities against BRD4 (IC50 = 180 nM) and CK2 (IC50 = 230 nM). In vitro experiments show that 44e could inhibit the proliferation and induce apoptosis and autophagy-associated cell death of MDA-MB-231 and MDA-MB-468 cells. In two in vivo xenograft mouse models, 44e displays potent anticancer activity without obvious toxicities. Taken together, we successfully synthesized the first highly effective BRD4–CK2 dual inhibitor, which is expected to be an attractive therapeutic strategy for triple-negative breast cancer (TNBC).

Design, synthesis and biological evaluation of hypolipidemic compounds based on BRD4 inhibitor RVX-208

Bromodomain-containing protein 4 (BRD4) is a new therapeutic target for the treatment of diseases including cardiovascular diseases, cancer, inflammation and central nervous system (CNS) disorders. In this study, we introduced the pharmacophore of fibrates to a BRD4 inhibitor, RVX-208, to design dual-active hypolipidemic compounds, and found that some of new analogues showed favorable hypolipidemic activities. Synthetic accessibility towards this class of compounds optimized RVX-208 as well as would supply more thoughts on hypolipidemic drugs.

Based on BRD4 inhibitor RVX - 208 of the derivative and its preparation method and application (by machine translation)

The invention discloses a method based on BRD4 inhibitor RVX - 208 of the derivative and its preparation method and application. Derivatives of the structure shown in formula I. The preparation method comprises: type 8 compound of formula 9 compound reaction, [...] 10 compound; type 10 compounds with malonic acid, d di-acid or fifth heavenly stem II acid after the reaction, with vinyl carbonate, 2 - halo of isobutyric acid or 4 - halo [...] butyric acid reaction; or, the type 10 compound directly with ethylene carbonate, 2 - halo of isobutyric acid or 4 - halo [...] butyric acid reaction. The invention also provides its application. The present invention provides based on BRD4 inhibitor RVX - 208 of the derivatives, can improve the activity or at the same time reducing cholesterol lowering cholesterol and triglyceride levels. (by machine translation)