ethyl 5-(tert-butoxymethyl)-1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-3-methyl-1H-pyrazole-4-carboxylate

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Chemical Name:ethyl 5-(tert-butoxymethyl)-1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-3-methyl-1H-pyrazole-4-carboxylate
CAS No.:1313196-62-1
Molecular Formula:C₂₇H₂₇ClF₂N₂O₃S
Molecular Weight:533.039
Hs Code.:

Synonyms:ethyl 5-(tert-butoxymethyl)-1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-3-methyl-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 5-(tert-butoxymethyl)-1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-3-methyl-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 5-(tert-butoxymethyl)-1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-3-methyl-1H-pyrazole-4-carboxylate

There total 4 articles about ethyl 5-(tert-butoxymethyl)-1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-3-methyl-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₇FN₂O₆S₂

: 328956-61-2
3-fluoro-5-chlorophenylboronic acid

: 1313196-62-1
ethyl 5-(tert-butoxymethyl)-1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-3-methyl-1H-pyrazole-4-carboxylate

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; at 60 ℃;

Reference yield:

: 1207970-48-6
(7-bromo-4-fluoro-1-benzothiophen-2-yl)methanol

: 1313196-62-1
ethyl 5-(tert-butoxymethyl)-1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-3-methyl-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 85 °C / Inert atmosphere

2: pyridine / copper(II) acetate monohydrate / 55 °C

3: triethylamine / dmap / tetrahydrofuran / 1 h / 10 - 35 °C / Inert atmosphere

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 60 °C

With pyridine; potassium acetate; caesium carbonate; triethylamine; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(II) acetate monohydrate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1313196-38-1
[4-fluoro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzothiophen-2-yl]methanol

: 1313196-62-1
ethyl 5-(tert-butoxymethyl)-1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-3-methyl-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / copper(II) acetate monohydrate / 55 °C

2: triethylamine / dmap / tetrahydrofuran / 1 h / 10 - 35 °C / Inert atmosphere

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 60 °C

With pyridine; caesium carbonate; triethylamine; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(II) acetate monohydrate; In tetrahydrofuran; water;