1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxamide
CAS No.:1313197-77-1
Molecular Formula:C₂₃H₂₀ClF₂N₃O₃S
Molecular Weight:491.946
Hs Code.:

Synonyms:1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxamide

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Chemical Property of 1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxamide

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Technology Process of 1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxamide

There total 7 articles about 1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1313196-63-2
1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxylic acid

: 141-43-5
ethanolamine

: 1313197-77-1
1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: 1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 0.0833333h;

ethanolamine; In N,N-dimethyl-formamide;

Reference yield:

: 1207970-48-6
(7-bromo-4-fluoro-1-benzothiophen-2-yl)methanol

: 1313197-77-1
1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 85 °C / Inert atmosphere

2: pyridine / copper(II) acetate monohydrate / 55 °C

3: triethylamine / dmap / tetrahydrofuran / 1 h / 10 - 35 °C / Inert atmosphere

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 60 °C

5: hydrogenchloride; water / ethyl acetate

6: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 85 °C

7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 10 - 35 °C

With pyridine; hydrogenchloride; water; potassium acetate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1313196-38-1
[4-fluoro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzothiophen-2-yl]methanol

: 1313197-77-1
1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / copper(II) acetate monohydrate / 55 °C

2: triethylamine / dmap / tetrahydrofuran / 1 h / 10 - 35 °C / Inert atmosphere

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 60 °C

4: hydrogenchloride; water / ethyl acetate

5: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 85 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 10 - 35 °C

With pyridine; hydrogenchloride; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;