1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxylic acid

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Chemical Name:1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxylic acid
CAS No.:1313196-63-2
Molecular Formula:C₂₁H₁₅ClF₂N₂O₃S
Molecular Weight:448.878
Hs Code.:

Synonyms:1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxylic acid

There total 6 articles about 1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₁₉ClF₂N₂O₃S

: 1313196-63-2
1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: C₂₃H₁₉ClF₂N₂O₃S; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 85 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water;

Reference yield:

: 1207970-48-6
(7-bromo-4-fluoro-1-benzothiophen-2-yl)methanol

: 1313196-63-2
1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 85 °C / Inert atmosphere

2: pyridine / copper(II) acetate monohydrate / 55 °C

3: triethylamine / dmap / tetrahydrofuran / 1 h / 10 - 35 °C / Inert atmosphere

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 60 °C

5: hydrogenchloride; water / ethyl acetate

6: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 85 °C

With pyridine; hydrogenchloride; water; potassium acetate; caesium carbonate; triethylamine; sodium hydroxide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1313196-38-1
[4-fluoro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzothiophen-2-yl]methanol

: 1313196-63-2
1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-5-(hydroxymethyl)-3-methyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / copper(II) acetate monohydrate / 55 °C

2: triethylamine / dmap / tetrahydrofuran / 1 h / 10 - 35 °C / Inert atmosphere

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 60 °C

4: hydrogenchloride; water / ethyl acetate

5: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 85 °C

With pyridine; hydrogenchloride; water; caesium carbonate; triethylamine; sodium hydroxide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; water; ethyl acetate;