5-(4-[tert-butyl(dimethyl)silyloxy]phenyl)-3-phenyl-2-pyrazinamine

Base Information

• Chemical Name: 5-(4-[tert-butyl(dimethyl)silyloxy]phenyl)-3-phenyl-2-pyrazinamine
• CAS No.: 625848-40-0
• Molecular Formula: C₂₂H₂₇N₃OSi
• Molecular Weight: 377.561
• Mol file: 625848-40-0.mol

Synonyms:5-(4-[tert-butyl(dimethyl)silyloxy]phenyl)-3-phenyl-2-pyrazinamine

Chemical Property of 5-(4-[tert-butyl(dimethyl)silyloxy]phenyl)-3-phenyl-2-pyrazinamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-[tert-butyl(dimethyl)silyloxy]phenyl)-3-phenyl-2-pyrazinamine

There total 8 articles about 5-(4-[tert-butyl(dimethyl)silyloxy]phenyl)-3-phenyl-2-pyrazinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.1%

2-amino-3-bromo-5-[p-(t-butyldimethylsilyloxy)phenyl]-1,4-pyrazine (1178890-01-1) + phenylboronic acid (98-80-6) → 5-(4-[tert-butyl(dimethyl)silyloxy]phenyl)-3-phenyl-2-pyrazinamine (625848-40-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In ethanol; water; toluene; for 17h; Inert atmosphere; Reflux;

Reference yield: 68.0%

(4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid (159191-56-7) + 5-bromo-3-phenyl-pyrazin-2-amine (344940-70-1) → 5-(4-[tert-butyl(dimethyl)silyloxy]phenyl)-3-phenyl-2-pyrazinamine (625848-40-0)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; sodium carbonate; 1,4-di(diphenylphosphino)-butane; In ethanol; water; toluene; for 0.116667h; Heating;

DOI:10.1016/j.tet.2003.08.040

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 5-(4-[tert-butyl(dimethyl)silyloxy]phenyl)-3-phenyl-2-pyrazinamine (625848-40-0)

Guidance literature:

Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide; water

2: hydrogenchloride; n-butyllithium / hexane; tetrahydrofuran

3: sodium carbonate / dichlorobis(triphenylphosphine)palladium[II] / toluene; ethanol; water

4: N-Bromosuccinimide / water; dimethyl sulfoxide

5: sodium carbonate / dichlorobis(triphenylphosphine)palladium[II] / toluene; ethanol; water

With hydrogenchloride; N-Bromosuccinimide; n-butyllithium; sodium carbonate; dichlorobis(triphenylphosphine)palladium[II]; In tetrahydrofuran; ethanol; hexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

upstream raw materials:

(4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid

5-bromo-3-phenyl-pyrazin-2-amine

phenylboronic acid

tert-butyldimethylsilyl chloride

Downstream raw materials:

2-[4-(tert-Butyldimethylsilyloxy)phenyl]-N-{5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-phenylpyrazin-2-yl}acetamide

2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-phenylpyrazin-2-yl]acetamide