(2R,3S)-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (1R,2S)-2-phenylcyclohexyl ester

Base Information

Chemical Name:(2R,3S)-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (1R,2S)-2-phenylcyclohexyl ester
CAS No.:128232-03-1
Molecular Formula:C₂₂H₂₄O₄
Molecular Weight:352.43
Hs Code.:

Synonyms:(2R,3S)-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (1R,2S)-2-phenylcyclohexyl ester

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Chemical Property of (2R,3S)-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (1R,2S)-2-phenylcyclohexyl ester

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Technology Process of (2R,3S)-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (1R,2S)-2-phenylcyclohexyl ester

There total 3 articles about (2R,3S)-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (1R,2S)-2-phenylcyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 123-11-5
4-methoxy-benzaldehyde

: 128300-47-0
(-)-trans-2-phenylcyclohexyl chloroacetate

: 138382-01-1
(2S,3R)-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (1R,2S)-2-phenylcyclohexyl ester

: 128232-03-1
(2R,3S)-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (1R,2S)-2-phenylcyclohexyl ester

Guidance literature:: With sodium hydride; 1.)hexanes, THF, r. t., overnight, 2.) 55-60 deg C, 1 h;
DOI:10.1021/jo00029a013

Reference yield:

hexanes-ethyl acetate: hexanes-ethyl acetate

: 7664-93-9
sulfuric acid

: 123-11-5
4-methoxy-benzaldehyde

: 128300-47-0
(-)-trans-2-phenylcyclohexyl chloroacetate

: 128232-03-1
(2R,3S)-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (1R,2S)-2-phenylcyclohexyl ester

Guidance literature:: With NaH; In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane; dichloromethane; mineral oil;

Reference yield:

: 98919-68-7
(1R,2S)-trans-2-phenylcyclohexanol

: 128232-03-1
(2R,3S)-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (1R,2S)-2-phenylcyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / DMAP / CH₂Cl₂ / 8 h / Heating

2: 52 percent / NaH / 1.)hexanes, THF, r. t., overnight, 2.) 55-60 deg C, 1 h

With dmap; sodium hydride; In dichloromethane;
DOI:10.1021/jo00029a013