O-(tert-butyl) S-cyclohexyl thiocarbonate

Base Information

• Chemical Name: O-(tert-butyl) S-cyclohexyl thiocarbonate
• CAS No.: 162222-10-8
• Molecular Formula: C₁₁H₂₀O₂S
• Molecular Weight: 216.345
• Mol file: 162222-10-8.mol

Synonyms:O-(tert-butyl) S-cyclohexyl thiocarbonate

Chemical Property of O-(tert-butyl) S-cyclohexyl thiocarbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-(tert-butyl) S-cyclohexyl thiocarbonate

There total 1 articles about O-(tert-butyl) S-cyclohexyl thiocarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Cyclohexanethiol (1569-69-3) + di-tert-butyl dicarbonate (24424-99-5) → O-(tert-butyl) S-cyclohexyl thiocarbonate (162222-10-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00313

Reference yield: 96.0%

O-(tert-butyl) S-cyclohexyl thiocarbonate (162222-10-8) + 2-methylphenyl triflate (66107-34-4) → S-cyclohexyl 2-methylbenzothioate

Guidance literature:

With 1,10-Phenanthroline; (1,2-dimethoxyethane)dichloronickel(II); tetrabutyl-ammonium chloride; magnesium bromide; zinc; In N,N-dimethyl acetamide; at 80 ℃; for 12h; chemoselective reaction; Schlenk technique; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.1c00313

Reference yield: 95.0%

O-(tert-butyl) S-cyclohexyl thiocarbonate (162222-10-8) + 1,3-dihydroisobenzofuran-5-yl trifluoromethanesulfonate (109586-40-5) → S-cyclohexyl benzo[d][1,3]dioxole-5-carbothioate

Guidance literature:

With 1,10-Phenanthroline; (1,2-dimethoxyethane)dichloronickel(II); tetrabutyl-ammonium chloride; magnesium bromide; zinc; In N,N-dimethyl acetamide; at 80 ℃; for 12h; chemoselective reaction; Schlenk technique; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.1c00313

upstream raw materials:

Cyclohexanethiol

di-tert-butyl dicarbonate

Downstream raw materials:

S-cyclohexyl 4-methoxybenzothioate

S-cyclohexyl 4-methylbenzothioate

S-cyclohexyl benzothioate

1,2-dicyclohexyl disulfide

Refernces

• 1、 Temperini, Andrea,Annesi, Diego,Testaferri, Lorenzo,Tiecco, Marcello. "A simple acylation of thiols with anhydrides". supporting information; experimental part. p. 5368 - 5371. Retrieved 2010/10/20.