benzoic acid 3-[(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-trimethylsilanylmethyl-amino]-3-trimethylsilanyl-propyl ester

Base Information

• Chemical Name: benzoic acid 3-[(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-trimethylsilanylmethyl-amino]-3-trimethylsilanyl-propyl ester
• CAS No.: 864653-61-2
• Molecular Formula: C₂₅H₃₆INO₄Si₂
• Molecular Weight: 597.641
• Mol file: 864653-61-2.mol

Synonyms:benzoic acid 3-[(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-trimethylsilanylmethyl-amino]-3-trimethylsilanyl-propyl ester

Chemical Property of benzoic acid 3-[(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-trimethylsilanylmethyl-amino]-3-trimethylsilanyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzoic acid 3-[(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-trimethylsilanylmethyl-amino]-3-trimethylsilanyl-propyl ester

There total 6 articles about benzoic acid 3-[(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-trimethylsilanylmethyl-amino]-3-trimethylsilanyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-trimethylsilanylmethyl-amino]-3-trimethylsilanyl-propan-1-ol + benzoyl chloride (98-88-4) → benzoic acid 3-[(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-trimethylsilanylmethyl-amino]-3-trimethylsilanyl-propyl ester (864653-61-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/ol051321o

Reference yield:

3-amino-1-propanol (864653-63-4) → benzoic acid 3-[(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-trimethylsilanylmethyl-amino]-3-trimethylsilanyl-propyl ester (864653-61-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile / 8 h / Heating

2: 6 g / triethylamine / CH₂Cl₂ / 6 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/ol051321o

Reference yield:

2-Methyl-4-trimethylsilanyl-[1,3]oxazinane-3-carboxylic acid tert-butyl ester (146514-22-9) → benzoic acid 3-[(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-trimethylsilanylmethyl-amino]-3-trimethylsilanyl-propyl ester (864653-61-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / HCl / dioxane / 1 h / Heating

2: 80 percent / K₂CO₃ / acetonitrile / 10 h / Heating

3: K₂CO₃ / acetonitrile / 8 h / Heating

4: 6 g / triethylamine / CH₂Cl₂ / 6 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1021/ol051321o

upstream raw materials:

benzoyl chloride

3-amino-3-(trimethylsilyl)propan-1-ol

3-amino-1-propanol

2-Methyl-4-trimethylsilanyl-[1,3]oxazinane-3-carboxylic acid tert-butyl ester

Downstream raw materials:

benzoic acid 3-{[6-(3-oxo-but-1-enyl)-benzo[1,3]dioxol-5-ylmethyl]-trimethylsilanylmethyl-amino}-3-trimethylsilanyl-propyl ester