4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one

Base Information

Chemical Name:4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one
CAS No.:1330676-49-7
Molecular Formula:C₂₉H₂₄F₂N₄O₆
Molecular Weight:562.53
Hs Code.:

Synonyms:4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one

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Chemical Property of 4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one

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Technology Process of 4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one

There total 3 articles about 4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2
Hippuric Acid

: 1330676-41-9
4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzaldehyde

: 1330676-49-7
4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one

Guidance literature:: With sodium acetate; acetic anhydride; at 85 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.06.022

Reference yield:

: 86386-76-7,123632-22-4,141113-42-0,150024-48-9
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

: 1330676-49-7
4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium carbonate / ethyl acetate / 12 h / 80 °C / Inert atmosphere

2: sodium acetate; acetic anhydride / 2 h / 85 °C / Inert atmosphere

With tetrabutylammomium bromide; sodium acetate; acetic anhydride; potassium carbonate; In ethyl acetate;
DOI:10.1016/j.bmcl.2011.06.022

Reference yield:

: 134-96-3
syringic aldehyde

: 1330676-49-7
4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium carbonate / ethyl acetate / 12 h / 80 °C / Inert atmosphere

2: sodium acetate; acetic anhydride / 2 h / 85 °C / Inert atmosphere

With tetrabutylammomium bromide; sodium acetate; acetic anhydride; potassium carbonate; In ethyl acetate;
DOI:10.1016/j.bmcl.2011.06.022