4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzaldehyde

Base Information

• Chemical Name: 4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzaldehyde
• CAS No.: 1330676-41-9
• Molecular Formula: C₂₀H₁₉F₂N₃O₅
• Molecular Weight: 419.385
• Mol file: 1330676-41-9.mol

Synonyms:4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzaldehyde

Chemical Property of 4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzaldehyde

There total 1 articles about 4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole (86386-76-7,123632-22-4,141113-42-0,150024-48-9) + syringic aldehyde (134-96-3) → 4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzaldehyde (1330676-41-9)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In ethyl acetate; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.06.022

Reference yield: 94.0%

2-thioxo-4-thiazolidinone (141-84-4) + 4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzaldehyde (1330676-41-9) → 5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-thioxothiazolidin-4-one (1330676-84-0)

Guidance literature:

With sodium acetate; In acetic acid; at 85 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.06.022

Reference yield: 93.0%

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) + 4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzaldehyde (1330676-41-9) → 4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one (1330676-49-7)

Guidance literature:

With sodium acetate; acetic anhydride; at 85 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.06.022

upstream raw materials:

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

syringic aldehyde

Downstream raw materials:

4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-phenyloxazol-5(4H)-one

5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)-3,5-dimethoxybenzylidene)-2-thioxothiazolidin-4-one