3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one

Base Information

Chemical Name:3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
CAS No.:1450627-72-1
Molecular Formula:C₁₄H₁₅FN₄O₂
Molecular Weight:290.297
Hs Code.:

Synonyms:3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one

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Chemical Property of 3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one

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Technology Process of 3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one

There total 5 articles about 3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1450627-91-4
C₁₃H₁₃FN₄O₂

: 1450627-72-1
3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one

Guidance literature:: With hydrogenchloride; In water; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2013.06.069

Reference yield:

: 67-56-1
methanol

: 1450627-89-0
5-amino-1-(4-fluorobenzyl)-N-(2,2-dimethoxyethyl)-1H-imidazole-4-carboxamide

: 1450627-72-1
3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one

Guidance literature:: With hydrogenchloride; water; at 50 ℃; for 24h;
DOI:10.1016/j.bmc.2013.06.069

Reference yield:

: 1450627-81-2
(E)-1-(4-fluorobenzyl)-5-nitro-4-styryl-1H-imidazole

: 1450627-72-1
3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; potassium permanganate / water / 0 - 5 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / Reflux; Inert atmosphere

2.2: 2 h / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / methanol / 5 h / 2068.65 Torr

4.1: hydrogenchloride; water / 24 h / 50 °C

With hydrogenchloride; potassium permanganate; palladium on activated charcoal; water; hydrogen; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2013.06.069