3,7-diphenyl-3-hydroxy-7-methoxy-4,5-benzo-1,2-dioxacycloheptane

Base Information

• Chemical Name: 3,7-diphenyl-3-hydroxy-7-methoxy-4,5-benzo-1,2-dioxacycloheptane
• CAS No.: 131618-97-8
• Molecular Formula: C₂₂H₂₀O₄
• Molecular Weight: 348.398
• Mol file: 131618-97-8.mol

Synonyms:3,7-diphenyl-3-hydroxy-7-methoxy-4,5-benzo-1,2-dioxacycloheptane

Chemical Property of 3,7-diphenyl-3-hydroxy-7-methoxy-4,5-benzo-1,2-dioxacycloheptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,7-diphenyl-3-hydroxy-7-methoxy-4,5-benzo-1,2-dioxacycloheptane

There total 4 articles about 3,7-diphenyl-3-hydroxy-7-methoxy-4,5-benzo-1,2-dioxacycloheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

(Z)-o-(2-phenyl-3-methoxy-2-propenyl)benzophenone (131618-94-5) → 2-(2-benzoylphenyl)-1-phenylethan-1-one (53067-91-7) + 2,3-diphenylindene ozonide (131618-95-6,91859-82-4) + 3,7-diphenyl-3-hydroxy-7-methoxy-4,5-benzo-1,2-dioxacycloheptane (131618-97-8)

Guidance literature:

With methanol; ozone; In dichloromethane; at -78 ℃;

DOI:10.1021/ja00005a050

Reference yield: 49.0%

methanol (67-56-1) + (Z)-o-(2-phenyl-3-methoxy-2-propenyl)benzophenone (131618-94-5) → 2-(2-benzoylphenyl)-1-phenylethan-1-one (53067-91-7) + 2,3-diphenylindene ozonide (131618-95-6,91859-82-4) + 3,7-diphenyl-3-hydroxy-7-methoxy-4,5-benzo-1,2-dioxacycloheptane (131618-97-8)

Guidance literature:

With ozone; In dichloromethane; at -70 ℃;

DOI:10.1021/ja00005a050

Reference yield:

2-(2-benzoylphenyl)-1-phenylethan-1-one (53067-91-7) → 3,7-diphenyl-3-hydroxy-7-methoxy-4,5-benzo-1,2-dioxacycloheptane (131618-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) PhLi / 1.) ether, -10 deg C, 2.) 20 deg C, 20 h

2: 14 percent / O₃, CH₃OH / CH₂Cl₂ / -78 °C

With methanol; ozone; phenyllithium; In dichloromethane;

DOI:10.1021/ja00005a050

upstream raw materials:

methanol

(Z)-o-(2-phenyl-3-methoxy-2-propenyl)benzophenone

2-(2-benzoylphenyl)-1-phenylethan-1-one

(E)-o-(2-phenyl-3-methoxy-2-propenyl)benzophenone

Downstream raw materials:

3,7-dimethoxy-3,7-diphenyl-4,5-benzo-1,2-dioxacycloheptane

2,3-diphenylindene ozonide