Etrabamine

Base Information

• Chemical Name: Etrabamine
• CAS No.: 70590-58-8
• Molecular Formula: C₈H₁₂N₂S
• Molecular Weight: 168.263
• Mol file: 70590-58-8.mol

Synonyms:(Methyl)(4,5,6,7-tetrahydrobenzothiazol-6-yl)amine;Etrabamine

Chemical Property of Etrabamine

Chemical Property:

• Vapor Pressure: 0.00206mmHg at 25°C
• Boiling Point: 290.5°C at 760 mmHg
• Flash Point: 129.5°C
• PSA: 53.16000
• Density: 1.16g/cm³
• LogP: 1.61070

Purity/Quality:

ETRABAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Etrabamine

There total 6 articles about Etrabamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

→ Etrabamine (70590-58-8)

Guidance literature:

Reference yield: 37.0%

4,7-dihydrobenzothiazol-6(5H)-one (70590-43-1) + methylamine (74-89-5) → Etrabamine (70590-58-8)

Guidance literature:

With hydrogen; nickel; In ethanol; at 90 ℃; for 22h; under 67505.4 Torr;

Reference yield:

4-oxopimelate (6317-49-3) → Etrabamine (70590-58-8)

Guidance literature:

Multi-step reaction with 5 steps

1: Br₂ / diethyl ether

2: 50 percent / ethanol / 48 h / 20 °C

3: 72 percent / Na, Et₂O / 24 h / Ambient temperature

4: 85 percent / HCl / 30 h / Heating

5: 37 percent / H₂ / Raney Ni / ethanol / 22 h / 90 °C / 67505.4 Torr

With hydrogenchloride; diethyl ether; hydrogen; bromine; sodium; nickel; In diethyl ether; ethanol;

upstream raw materials:

4,7-dihydrobenzothiazol-6(5H)-one

methylamine

4-oxopimelate

diethyl 3-bromo-4-oxoheptanedioate

Refernces

• 1、 Maillard,Delaunay,Langlois,et al.. "Synthesis of aminoderivatives of 4,5,6,7-tetrahydro-benzothiazole. I. 4,5,6- and 7-amino and N-methyl amino derivatives with central dopaminergic activity". . p. 451 - 456. Retrieved 2007/10/02.