2-phenyl-N-[6-piperazin-1-ylpyridin-3-yl]-5-trifluoromethyl-1,3-oxazole-4-carboxamide hydrochloride

Base Information

Chemical Name:2-phenyl-N-[6-piperazin-1-ylpyridin-3-yl]-5-trifluoromethyl-1,3-oxazole-4-carboxamide hydrochloride
CAS No.:1085841-68-4
Molecular Formula:C₂₀H₁₈F₃N₅O₂*ClH
Molecular Weight:453.851
Hs Code.:

Synonyms:2-phenyl-N-[6-piperazin-1-ylpyridin-3-yl]-5-trifluoromethyl-1,3-oxazole-4-carboxamide hydrochloride

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Chemical Property of 2-phenyl-N-[6-piperazin-1-ylpyridin-3-yl]-5-trifluoromethyl-1,3-oxazole-4-carboxamide hydrochloride

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Technology Process of 2-phenyl-N-[6-piperazin-1-ylpyridin-3-yl]-5-trifluoromethyl-1,3-oxazole-4-carboxamide hydrochloride

There total 5 articles about 2-phenyl-N-[6-piperazin-1-ylpyridin-3-yl]-5-trifluoromethyl-1,3-oxazole-4-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

: 1085836-67-4
4-{5-[(2-phenyl-5-trifluoromethyloxazole-4-carbonyl)amino]pyridin-2-yl}piperazine-1-carboxylic acid tert-butyl ester

: 1085841-68-4
2-phenyl-N-[6-piperazin-1-ylpyridin-3-yl]-5-trifluoromethyl-1,3-oxazole-4-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm101580m

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1085841-68-4
2-phenyl-N-[6-piperazin-1-ylpyridin-3-yl]-5-trifluoromethyl-1,3-oxazole-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 80 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 2585.81 Torr

3: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: hydrogenchloride / methanol; diethyl ether; dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm101580m

Reference yield:

: 193902-78-2
tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate

: 1085841-68-4
2-phenyl-N-[6-piperazin-1-ylpyridin-3-yl]-5-trifluoromethyl-1,3-oxazole-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 2585.81 Torr

2: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: hydrogenchloride / methanol; diethyl ether; dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101580m