4-(4-Chlorophenyl)-1-(3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propyl)-4-piperidinol

Base Information

Chemical Name:4-(4-Chlorophenyl)-1-(3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propyl)-4-piperidinol
CAS No.:5499-80-9
Molecular Formula:C₂₈H₃₁ClN₂O
Molecular Weight:447.02
Hs Code.:

Synonyms:4-(4-Chlorophenyl)-1-(3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propyl)-4-piperidinol

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Chemical Property of 4-(4-Chlorophenyl)-1-(3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propyl)-4-piperidinol

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Technology Process of 4-(4-Chlorophenyl)-1-(3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propyl)-4-piperidinol

There total 3 articles about 4-(4-Chlorophenyl)-1-(3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propyl)-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 39512-49-7
4-(4-chlorophenyl)-4-hydroxypiperidine

: 16036-79-6
5-(3-chloropropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine

: 5499-80-9
4-(4-Chlorophenyl)-1-(3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propyl)-4-piperidinol

Guidance literature:: With sodium carbonate; sodium iodide; In acetonitrile; at 160 ℃; for 0.25h; under 12901 Torr; microwave irradiation;
DOI:10.1016/j.bmc.2006.06.054

Reference yield:

: 494-19-9
9,10-dihydrodibenzazepine

: 5499-80-9
4-(4-Chlorophenyl)-1-(3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propyl)-4-piperidinol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dibutyl ether / 3.5 h / Heating

1.2: 27 percent / dibutyl ether / Heating

2.1: 71 percent / sodium iodide; sodium carbonate / acetonitrile / 0.25 h / 160 °C / 12901 Torr / microwave irradiation

With sodium hydride; sodium carbonate; sodium iodide; In dibutyl ether; acetonitrile;
DOI:10.1016/j.bmc.2006.06.054