5-(3-CHLORO-PROPYL)-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE

Base Information

• Chemical Name: 5-(3-CHLORO-PROPYL)-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE
• CAS No.: 16036-79-6
• Molecular Formula: C17H18ClN
• Molecular Weight: 271.79
• Hs Code.: 2933990090
• Mol file: 16036-79-6.mol

Synonyms:5-(3-CHLORO-PROPYL)-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE;5-(3-Chloropropyl)-10,11-dihydro-5H-dibenz[b,f]azepine;NSC 145945

Chemical Property of 5-(3-CHLORO-PROPYL)-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE

Chemical Property:

• Vapor Pressure: 1.18E-06mmHg at 25°C
• Melting Point: 43-45°C
• Boiling Point: 401.5°C at 760 mmHg
• PKA: 1.86±0.20(Predicted)
• Flash Point: 196.6°C
• PSA: 3.24000
• Density: 1.13g/cm³
• LogP: 4.61720
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Dichloromethane, DMSO, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

5-(3-Chloropropyl)-10,11-dihydro-5H-dibenz[b,f]azepine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A dibenzazepine derivative for the synthesis of many pain, anti-inflammatory and psychopharmacological agents.

Technology Process of 5-(3-CHLORO-PROPYL)-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE

There total 9 articles about 5-(3-CHLORO-PROPYL)-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

9,10-dihydrodibenzazepine (494-19-9) + 1.3-chlorobromopropane (109-70-6) → 5-(3-chloropropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine (16036-79-6)

Guidance literature:

9,10-dihydrodibenzazepine; With sodium amide; In toluene; at 25 ℃; for 0.5h;

1.3-chlorobromopropane; In toluene; at 115 ℃; for 14h;

DOI:10.1016/j.bmc.2017.12.047

Reference yield: 23.0%

9,10-dihydrodibenzazepine (494-19-9) + 1.3-chlorobromopropane (109-70-6) → 5-allyl-10,11-dihydro-5H-dibenzoazepine (74074-21-8) + 5-(3-chloropropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine (16036-79-6)

Guidance literature:

9,10-dihydrodibenzazepine; With n-butyllithium; In tetrahydrofuran; hexane; benzene; at 0 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

1.3-chlorobromopropane; In tetrahydrofuran; hexane; benzene; at 20 ℃; for 3.5h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.bmc.2015.06.044

Reference yield:

borontrifluoride diethyl etherate + 3-chloro-1-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-1-propanone (19054-67-2) → 5-(3-chloropropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine (16036-79-6)

Guidance literature:

With sodium borohydrid; In tetrahydrofuran; n-heptane; water; acetic acid; ethyl acetate;

upstream raw materials:

3-chloro-1-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-1-propanone

9,10-dihydrodibenzazepine

1.3-chlorobromopropane

1-bromo-1-chloropropane

Downstream raw materials:

4-(4-Chlorophenyl)-1-(3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propyl)-4-piperidinol

didesmethylimipramine

1-(3-(10,11-dihydro-5H-dibenz[b,f]-azepin-5-yl)-1-propyl)-4-piperidineacetic acid ethyl ester

5-[3-(N-trideuteromethylamino)propyl]iminodibenzyl

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