2-(4-chlorophenyl)-2-oxoethyl 4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)-phenyl)piperidin-1-yl)methyl)butanoate

Base Information

Chemical Name:2-(4-chlorophenyl)-2-oxoethyl 4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)-phenyl)piperidin-1-yl)methyl)butanoate
CAS No.:1609575-69-0
Molecular Formula:C₂₅H₂₄ClF₆NO₃
Molecular Weight:535.914
Hs Code.:

Synonyms:2-(4-chlorophenyl)-2-oxoethyl 4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)-phenyl)piperidin-1-yl)methyl)butanoate

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Chemical Property of 2-(4-chlorophenyl)-2-oxoethyl 4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)-phenyl)piperidin-1-yl)methyl)butanoate

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Technology Process of 2-(4-chlorophenyl)-2-oxoethyl 4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)-phenyl)piperidin-1-yl)methyl)butanoate

There total 4 articles about 2-(4-chlorophenyl)-2-oxoethyl 4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)-phenyl)piperidin-1-yl)methyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1602924-01-5
4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid

: 536-38-9
4-chlorobenzoylmethyl bromide

: 1609575-69-0
2-(4-chlorophenyl)-2-oxoethyl 4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)-phenyl)piperidin-1-yl)methyl)butanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 328-62-1
4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

: 1609575-69-0
2-(4-chlorophenyl)-2-oxoethyl 4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)-phenyl)piperidin-1-yl)methyl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / tetrahydrofuran; water / 0.33 h / 0 °C

1.2: 0.5 h

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

3.1: sodium hydroxide; ethanol / 0.5 h / 90 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With ethanol; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 4,4,4-trifluoro-3-formyl-butyric acid ethyl ester

: 1609575-69-0
2-(4-chlorophenyl)-2-oxoethyl 4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)-phenyl)piperidin-1-yl)methyl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

2: sodium hydroxide; ethanol / 0.5 h / 90 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With ethanol; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;