4-(5-ethylpyrimidin-2-yloxy)-N-(4-(methylsulfonyl)benzyl)cyclohexane carboxamide

Base Information

Chemical Name:4-(5-ethylpyrimidin-2-yloxy)-N-(4-(methylsulfonyl)benzyl)cyclohexane carboxamide
CAS No.:1361392-18-8
Molecular Formula:C₂₁H₂₇N₃O₄S
Molecular Weight:417.529
Hs Code.:

Synonyms:4-(5-ethylpyrimidin-2-yloxy)-N-(4-(methylsulfonyl)benzyl)cyclohexane carboxamide

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Chemical Property of 4-(5-ethylpyrimidin-2-yloxy)-N-(4-(methylsulfonyl)benzyl)cyclohexane carboxamide

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Technology Process of 4-(5-ethylpyrimidin-2-yloxy)-N-(4-(methylsulfonyl)benzyl)cyclohexane carboxamide

There total 2 articles about 4-(5-ethylpyrimidin-2-yloxy)-N-(4-(methylsulfonyl)benzyl)cyclohexane carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1361392-17-7
4-(5-ethylpyrimidin-2-yloxy)cyclohexanecarboxylic acid

: 98593-51-2
4-(methylsulfonyl)benzylamine hydrochloride

: 1361392-18-8
4-(5-ethylpyrimidin-2-yloxy)-N-(4-(methylsulfonyl)benzyl)cyclohexane carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 3685-22-1,3685-26-5,17419-81-7
4-hydroxycyclohexanecarboxylic acid

: 1361392-18-8
4-(5-ethylpyrimidin-2-yloxy)-N-(4-(methylsulfonyl)benzyl)cyclohexane carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil / 0.5 h / 0 - 20 °C

1.2: 15 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide; mineral oil;