(+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine

Base Information

• Chemical Name: (+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine
• CAS No.: 109765-74-4
• Molecular Formula: C₂₅H₃₀FNO₃
• Molecular Weight: 411.517
• Mol file: 109765-74-4.mol

Synonyms:(+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine

Chemical Property of (+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine

There total 3 articles about (+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

propionic acid anhydride (123-62-6) + (+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol (109765-71-1) → (+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine (109765-74-4,130549-78-9)

Guidance literature:

With pyridine; for 2h; Heating;

DOI:10.1021/jm00393a037

Reference yield:

(+/-)-(β)-1-benzyl-3-methyl-4-phenyl-4-piperidinol hydrochloride (109765-67-5) → (+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine (109765-74-4,130549-78-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethanol; H₂O / 24 h / 50 - 60 °C / 1520 Torr

2: KI, Na₂CO₃ / toluene / 48 h / Heating

3: 49 percent / pyridine / 2 h / Heating

With pyridine; hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In ethanol; water; toluene;

DOI:10.1021/jm00393a037

Reference yield:

(+/-)-(β)-3-methyl-4-phenyl-4-piperidinol (109765-69-7) → (+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine (109765-74-4,130549-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: KI, Na₂CO₃ / toluene / 48 h / Heating

2: 49 percent / pyridine / 2 h / Heating

With pyridine; sodium carbonate; potassium iodide; In toluene;

DOI:10.1021/jm00393a037

upstream raw materials:

propionic acid anhydride

(+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol

(+/-)-(β)-3-methyl-4-phenyl-4-piperidinol

(+/-)-(β)-1-benzyl-3-methyl-4-phenyl-4-piperidinol hydrochloride