2-(Dimethylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-3-phenylspiro-<4H-chromen-4,1'-cyclopropan>-5-on

Base Information

• Chemical Name: 2-(Dimethylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-3-phenylspiro-<4H-chromen-4,1'-cyclopropan>-5-on
• CAS No.: 120229-67-6
• Molecular Formula: C₂₃H₂₉NO₂
• Molecular Weight: 351.489

Synonyms:2-(Dimethylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-3-phenylspiro-<4H-chromen-4,1'-cyclopropan>-5-on

Chemical Property of 2-(Dimethylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-3-phenylspiro-<4H-chromen-4,1'-cyclopropan>-5-on

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Technology Process of 2-(Dimethylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-3-phenylspiro-<4H-chromen-4,1'-cyclopropan>-5-on

There total 2 articles about 2-(Dimethylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-3-phenylspiro-<4H-chromen-4,1'-cyclopropan>-5-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,5-Dimethyl-2-<1-(1-piperidinio)-cyclopropyl>-1-oxo-2-cyclohexen-3-olat (110174-70-4) → 2-(Dimethylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-3-phenylspiro-<4H-chromen-4,1'-cyclopropan>-5-on (120229-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / ethyldiisopropylamine / CH₂Cl₂

2: 2) 1,2-diaminoethan / 1) CH₂Cl₂, 4 h, reflux, 2) H₂O

With ethylenediamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

2-(1-piperidinocycloprop-1-yl)-5,5-dimethyl-3-oxocyclohex-1-en-1-yl acetate (110174-72-6) + diethylamino-1 phenyl-2 acetylene (4231-26-9) → 2-(Dimethylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-3-phenylspiro-<4H-chromen-4,1'-cyclopropan>-5-on (120229-67-6)

Guidance literature:

With ethylenediamine; Yield given. Multistep reaction; 1) CH₂Cl₂, 4 h, reflux, 2) H₂O;

Reference yield: 70.0%

2-(Dimethylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-3-phenylspiro-<4H-chromen-4,1'-cyclopropan>-5-on (120229-67-6) → 5,6,7,8-Tetrahydro-7,7-dimethyl-3-phenylspiro-2,5-dion (120262-50-2) + N,N-Diethyl-2-<1-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)cyclopropyl>-2-phenylacetamid (120229-80-3)

Guidance literature:

With sodium hydrogen sulfate; In dichloromethane; at 50 ℃; for 120h;

upstream raw materials:

2-(1-piperidinocycloprop-1-yl)-5,5-dimethyl-3-oxocyclohex-1-en-1-yl acetate

diethylamino-1 phenyl-2 acetylene

5,5-Dimethyl-2-<1-(1-piperidinio)-cyclopropyl>-1-oxo-2-cyclohexen-3-olat

Downstream raw materials:

5,6,7,8-Tetrahydro-7,7-dimethyl-3-phenylspiro-2,5-dion

N,N-Diethyl-2-<1-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)cyclopropyl>-2-phenylacetamid

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